文献类型：期刊文献

英文题名：GSH-responsive polymeric micelles based on the thio-ene reaction for controlled drug release

作者：Cao, Hongliang[1];Song, Huajie[1];Xie, Debiao[1];Chen, Chao[2,3];Chen, Xin[1,4];Wang, Ping[2,3];Wang, Wenxin[5]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Minist Educ,Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Biotechnol, Shanghai, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Biomed Nanotechnol Ctr, Shanghai, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, State Key Lab Funct Mat Informat, 865 Changning Rd, Shanghai 200050, Peoples R China;[5]Univ Coll Dublin, Sch Med & Med Sci, Charles Inst Dermatol, Dublin, Ireland

年份：2016

卷号：6

期号：84

起止页码：80896

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20163602781794);WOS:【SCI-EXPANDED(收录号:WOS:000383903500061)】；

基金：We gratefully acknowledge the financial support of Shanghai Pujiang Program (13PJ1401700). The support from the Shanghai Leading Academic Discipline Project (B502), the Shanghai Key Laboratory Project (08DZ2230500), the Science and Technology Commission of Shanghai Municipality Project (11nm0507000), the State Key Laboratory of Functional Materials for Informatics Open Project (SKL201306), and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry are acknowledged.

语种：英文

外文关键词：Controlled drug delivery - Sulfur compounds - Addition reactions - Polymer blends - Targeted drug delivery - Atom transfer radical polymerization

摘要：We report a glutathione (GSH) responsive drug carrier that is based on the Michael addition reaction between an olefinic bond and GSH. Amphiphilic copolymers with multi-linear-cyclized and branched structures that contain vinyl groups were successfully synthesized by deactivation enhanced atom transfer radical polymerization (DE-ATRP). The polymers self-assembled into GSH responsive micelles with sizes of 68 to 97 nm and spherical morphology. The core cross-linked micelles were confirmed to greatly decrease doxorubicin (DOX) leakage due to the concentration gradient. Drug release experiments indicated that the drug carrier containing no disulfide has the same responsive ability as a conventional GSH reduction responsive carrier with a similar polymer structure. MTT assays showed that the blank micelles are totally non-cytotoxic, while the DOX-loaded micelles exhibit GSH-dependent behaviour.