文献类型：期刊文献

英文题名：Cyanation of Unactivated Aryl Chlorides and Aryl Mesylates Catalyzed by Palladium and Hemilabile MOP-Type Ligands

作者：Tu, Yahui[1];Zhang, Yi[2];Xu, Sheng[1];Zhang, Zhaoguo[2];Xie, Xiaomin[2]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

年份：2014

卷号：25

期号：20

起止页码：2938

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000345902500020)】；

基金：We thank the National Natural Science Foundation of China for financial support.

语种：英文

外文关键词：palladium; monophosphine ligands; cyanation; aryl chlorides; aryl mesylates

摘要：Palladium-catalyzed cyanation of aryl halides and pseudo halides with potassium hexacyanoferrate is described employing the hemilabile, bulky, and electron-rich MOP-type ligands. When the mixture of t-BuOH and H2O was used as the solvent and K2CO3 as the base, the MOP-type ligands showed high efficiency for the palladium-catalyzed cyanation. The effect of ligand structure was studied in detail, and 2-di-tert-butylphosphino-2-isopropoxy-1,1-binaphthyl was the more effective for the cyanation. The catalyst system allows the cyanation of unactivated aryl chlorides, and even aryl mesylates to occur in good yields. Furthermore, the reactivity of different arylated reagents in the catalytic system was found to be: ArBr > ArCl >> ArOMs > ArOSO(2)Im > ArOSO2NMe2.