文献类型：期刊文献

英文题名：Mechanisms and characteristics of subcapsular sinus macrophages in tumor immunity: a narrative review

作者：Su, Feng[1,2];Zhang, Yutao[3,4];Maimaiti, Subinuer[5];Chen, Shanglin[1,2];Shen, Yaxing[1,2,6];Feng, Mingxiang[1,2];Guo, Zhiqiang[3,4];Tan, Lijie[1,2];He, Jie

机构：[1]Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Natl Clin Res Ctr Canc,Dept Thorac Surg, Beijing, Peoples R China;[2]Fudan Univ, Zhongshan Hosp, Dept Thorac Surg, Shanghai, Peoples R China;[3]East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Key Lab Adv Mat, Shanghai, Peoples R China;[4]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Shanghai, Peoples R China;[5]Fudan Univ, Coll Clin Med, Shanghai, Peoples R China;[6]Fudan Univ, Zhongshan Hosp, Dept Thorac Surg, 180 Fenglin Rd, Shanghai 200032, Peoples R China

年份：2023

卷号：12

期号：12

起止页码：3779

外文期刊名：TRANSLATIONAL CANCER RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001113160500001)】；

基金：This work was supported by the China Postdoctoral Science Foundation Grant (2018M631394), Science and Technology Innovation Plan of Shanghai Science and Technology Commission (22Y11907200) and the Special Fund for Clinical Research of Zhongshan Hospital (ZSLCYJ202336).

语种：英文

外文关键词：Macrophages; subcapsular sinus; tumor; immunity

摘要：Background and Objective: Lymph nodes constitute an integral component of the secondary lymphoid organs, housing a diverse population of macrophages. Macrophages exhibit heterogeneity in terms of localization, phenotype and ontogeny. Recent evidence has established that subcapsular sinus macrophages (SCSMs) are the initial cells exposed to antigens from afferent lymph vessels, playing a crucial role in the host immune response against invading pathogens and tumor cells. In order to summarize the role and mechanisms of SCSM in tumor immunity, this study systematically reviews research on SCSMs in tumor immunity.Methods: A systematic search was conducted in PubMed and Web of Science to identify articles investigating clinical significance and mechanisms of SCSMs. Study eligibility was independently evaluated by two authors based on the assessment of titles, abstracts and full-texts.Key Content and Findings: The narrative review included a total of 17 studies. Previous research consistently showed that a high level of SCSM in patients with various carcinomas is associated with a favorable long-term prognosis. SCSM acts as the front-line defender in antitumor activity, engaging in intricate communication with other immune cells. Moreover, SCSM could directly and indirectly modulate tumor immunity, and the integrity of SCSM layer is interrupted in disease status. Several studies explored the feasibility of targeting SCSM to activate immunity against tumors. However, the direct molecular interactions and alternation in signal pathway in the tumor immunity of SCSM are less well established in previous researches.Conclusions: This narrative review underscores the critical role of SCSM in tumor immunity. Future studies should focus on the deeper mechanism underlying SCSMs and explore their clinical applications.