文献类型：期刊文献

英文题名：cis-Nitromethylene neonicotinoids as new nicotinic family: Synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2-α]pyridine

作者：Shao, Xusheng[1];Zhang, Wenwen[1];Peng, Yanqing[1];Li, Zhong[1];Tian, Zhongzhen[1];Qian, Xuhong[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2008

卷号：18

期号：24

起止页码：6513

外文期刊名：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000261141100048)】；

基金：This work was financial supported by National Natural Science Foundation of China (20502006, 20572024), National High Technology Research and Development Program of China (863 Program, 2006AA10A201). The authors also appreciate the partly support from National Key Technology R D Program of China (2006BAE01A01-8), Shanghai Foundation of Science and Technology (064319022), Shanghai Leading Academic Discipline Project, Project Number: B507.

语种：英文

外文关键词：Neonicotinoid; cis-Configuration; Insecticide; Resistance

摘要：A series of neonicotinoids analogues of hexahydroimidazo[1,2-alpha]pyridine were modified at 5-, 6-, and 7-positions, and their insecticidal activities were evaluated. Introducing a methyl or ethyl at 7-position increased the insecticidal activities, while other substituents decreased activities. When alkyl substituents were introduced to 7-position, the insecticidal activities against Pea aphids decreased in the order methyl (7a) > ethyl (7b) > n-butyl (7e) > phenyl (7f) > n-propyl (7c) > iso-propyl (7d), p-NO2-phenyl (7g). Modifications at 5-, 6- or both at 6- and 7-positions with methyl or ethyl were unfavorable to activities. Interestingly, introducing methyl to 7-position not only increased insecticidal activities against pea aphids, but also show higher insecticidal activities than imidacloprid against imidacloprid-resistant brown planthopper. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.