文献类型：期刊文献

英文题名：Pendant Groups Fine-tuning Thermal Gelation of Poly(ε-caprolactone)-b-Poly(ethylene glycol)-b-Poly(ε-caprolactone) Aqueous Solution

作者：Zhang, Yan[1];Wang, Miao[1];Ye, Jinhai[2];Lang, Meidong[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Nanjing Med Univ, Inst Stomatol, Sch Stomatol, 136 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China

年份：2016

卷号：54

期号：16

起止页码：2571

外文期刊名：JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

收录：;EI(收录号：20161702304436);WOS:【SCI-EXPANDED(收录号:WOS:000383674100013)】；

基金：Financial support from the National Natural Science Foundation of China (21274039, 81371123), Shanghai Pujiang Program (14PJD014), 111 Project (B14018), Specialized Research Fund for the Doctoral Program of Higher Education (20130074110007) are gratefully acknowledged.

语种：英文

外文关键词：thermal gelation; phase transition; crystallization; pendant groups; poly(epsilon-caprolactone)

摘要：Novel poly(epsilon-caprolactone)-b-poly(ethylene glycol)-b- poly(epsilon-caprolactone) (PCL-PEG-PCL) bearing pendant hydrophobic c-(carbamic acid benzyl ester) groups (PECB) and hydrophiphilic amino groups (PECN) were synthesized based on the functionalized comonomer c-(carbamic acid benzyl ester)-epsilon-caprolactone (CABCL). The thermal gelation behavior of the amphiphilic copolymer aqueous solutions was examined. The phase transition behavior could be finely tuned via the pendant groups, and an abnormal phenomenon occurred that the solgel transition temperature shifted to a higher temperature for PECB whereas a lower temperature for PECN. The micelles percolation was adopted to clarify the hydrogel mechanism, and the effect of the pendant groups on the micellization was fur-ther investigated in detail. The results demonstrated that the introduction of c-(carbamic acid benzyl ester) pendant groups significantly decreased the crystallinity of the copolymer micelles whereas amino pendant groups made the micelles easy to aggregate. Thus, the thermal gelation of PEG/PCL aqueous solution could be finely tuned by the pendant groups, and the pendant groups modified PEG/PCL hydrogels are expected to have great potential biomedical application. (C) 2016 Wiley Periodicals, Inc.