文献类型：期刊文献

英文题名：Cu(OAc)2/FOXAP complex catalyzed construction of 2,5-dihydropyrrole derivatives via asymmetric 1,3-dipolar cycloaddition of azomethine ylides to ethynyl ketones

作者：Tang, Fei-Fei[1];Yang, Wu-Lin[1];Yu, Xingxin[1];Deng, Wei-Ping[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2015

卷号：5

期号：7

起止页码：3568

外文期刊名：CATALYSIS SCIENCE & TECHNOLOGY

收录：;EI(收录号：20152600979522);WOS:【SCI-EXPANDED(收录号:WOS:000356610600014)】；

基金：This work is supported by The Fundamental Research Funds for the Central Universities, the National Natural Science Foundation of China (no. 21172068 and no. 21402049), Shanghai Pujiang Program (no. 14PJD013), and Shanghai Yangfan Program (no. 14YF1404600).

语种：英文

外文关键词：Catalysis - Ketones

摘要：Catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides to ethynyl ketones catalyzed by the Cu(OAc)(2)/FOXAP (ferrocenyl oxazolinylphosphine) complex was developed, affording 2,5-dihydropyrrole derivatives in good to excellent yields (up to 99%) and excellent levels of enantioselectivities (up to 98% ee). This highly efficient chiral N, P-ligand/Cu(OAc)(2) catalytic system was also applicable for the 1,3-dipolar cycloaddition of alpha-arylglycine ester-generated azomethine ylides to ynones, affording exclusive quaternary carbon-containing cis-2,5-dihydropyrroles in excellent enantioselectivities (89-92% ee).