文献类型：期刊文献

英文题名：Synthesis, Crystal Structure, and Insecticidal Activities of Highly Congested Hexahydroimidazo[1,2-a]pyridine Derivatives: Effect of Conformation on Activities

作者：Shao, Xusheng[1];Xu, Zhiping[1];Zhao, Xianfeng[1];Xu, Xiaoyong[1];Tao, Limin[1];Zhong Li[1];Qian, Xuhong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2010

卷号：58

期号：5

起止页码：2690

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000275087600012)】；

基金：This work was Financially supported by the National Basic Research Program of China (973 Program, 2010CB126100), the National High Technology Research and Development Program of China (863 Program, 2006AA10A201), National Science Foundation China Program Grant (20872034), and the Program for New Century Excellent Talents in University (NCET070284). This work was also partly supported by the Shanghai Foundation of Science and Technology (08391911600, 0XD1401300, 073919107), the Grant "Application of Nuclear Techniques in Agriculture" from the Chinese Ministry of Agriculture (Grant 200803034), the Shanghai Leading Academic Discipline Project, Project B507.111 (No. 1307023).

语种：英文

外文关键词：Diels-Alder reaction; insecticide; conformation; activities

摘要：A series of hexahydroimidazo[1,2-a]pyridine derivatives were designed and synthesized through aza-Diels-Alder reactions and evaluated for insecticidal activities. Compounds 6a-d with endo-conformation were endowed with excellent insecticidal activities against cowpea aphid (Aphis craccivora) and armyworm (Pseudaletia separata Walker), whereas exo-compounds 7a-d showed only low activities against cowpea aphid. The difference in activities between the endo- and exo-conformations indicated that conformation was the determinant of life or death of the insects for these compounds.