文献类型：期刊文献

中文题名：磷酸钙骨粘合剂的研究

英文题名：Research on Calcium Phosphate Cement Bone Adhesive

作者：杨盛兵[1];王靖[1];刘昌胜[1]

机构：[1]华东理工大学超细材料制备与应用教育部重点实验室,教育部生物医用材料工程研究中心,上海200237

年份：2013

卷号：28

期号：1

起止页码：85

中文期刊名：无机材料学报

外文期刊名：Journal of Inorganic Materials

收录：CSTPCD;;EI(收录号：20131016087468);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000317589200013)】；北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：国家重大科学研究计划(2012CB933600)~~

语种：中文

中文关键词：磷酸钙;骨粘结;骨缺损;固化

外文关键词：calcium phosphate; bone adhesive; bone defect; solidification

摘要：在柠檬酸中添加壳聚糖配成的固化液与磷酸钙骨水泥(CPC)调和制备的骨修复材料具有类似口香糖的胶状特性,可应用于碎骨粘结,称之为磷酸钙骨粘合剂(CPCBA)。本研究考察了柠檬酸的含量对抗压强度、固化时间、水化产物和粘结强度的影响,同时对该体系进行了初步的体外生物学评价。结果显示,加入柠檬酸可以缩短固化时间并且时间可以通过柠檬酸的含量进行调控,同时也改善了抗水性能。壳聚糖可以与骨水泥中的钙离子发生螯合作用,可以增加界面的粘结强度。小鼠原成骨细胞(MC3T3-E1)在其表面粘附良好,该体系骨水泥有望取代PMMA成为新的骨粘结剂。
Using citric acid and chitosan as hardening liquid, and calcium phosphate cement （CPC） as powder, gum-like adhesive bone cement is obtained after mixing the powder and liquid components together, which can be used as calcium phosphate cement bone adhesive （CPCBA）. The effect of citric acid concentration on compressive strength, setting time and hydration products were investigated. In vitro cytocompatibility of the cements was also researched through cell culture on the cement surface. The results show that setting time is shorten and anti-washout is improved by introducing citric acid. Cohesion strength increases owing to chitosan chelated with calcium ion of CPC. The cements are transformed to hydroxyapatite after incubation 3 d in SBF and osteoblasts （MC3T3-E1） can attach and proliferate on the surface. Results indicate that the calcium phosphate cement bone adhesive is a suitable adhesive material for comminuted fracture.