文献类型：期刊文献

中文题名：硫氰酸红霉素在酸性溶液中的稳定性研究

英文题名：A study on stability of erythromycin thiocyanate in acid solution

作者：毛培学[1];陈葵[1];纪利俊[1];朱家文[1]

机构：[1]华东理工大学化学工程研究所,上海200237

年份：2013

卷号：38

期号：3

起止页码：218

中文期刊名：中国抗生素杂志

外文期刊名：Chinese Journal of Antibiotics

收录：CSTPCD;;Scopus;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

语种：中文

中文关键词：硫氰酸红霉素;降解;动力学

外文关键词：Erythromycin thiocyanate; Degradation; Kinetic

摘要：硫氰酸红霉素的生产是通过在酸性条件下反应结晶的方式制备,其稳定性直接影响产品的纯度。本文用磷酸缓冲盐溶液调节反应体系的pH,研究了硫氰酸红霉素各组分的降解率随pH的变化。结果表明,在硫氰酸红霉素的A、B、C 3种组分中,以活性组分A的稳定性受pH值的影响最大;pH在4.5时,硫氰酸红霉素A能够在40min内保持稳定,超过40min会发生降解;而当pH小于4.0时,硫氰酸红霉素A组分发生快速降解。文章探讨了红霉素A的降解机理,并研究了等摩尔硫氰酸根条件下红霉素A组分降解动力学,得到的模型与实验结果吻合良好,与文献对比,说明等摩尔硫氰酸根的存在降低了红霉素A的降解速率。
Erythromycin thiocyanate is producted in acid solution by reactive crystallization method, whose purity is effeeted by its acid stability. In this paper, pH was regulated by phosphate buffer and the stabilities of components of erythromycin thiocyanate under different pH were researched. The results show that during the three components of erythromycin thiocyanate, A, B and C, pH has the largest effect on the stability of A. When the pH is 4.5, erythromy- cin thiocyanate A can be steady in 40min and then will degradate; when pH is under 4.0, erythromycin thiocyanate A will degradate fastly. The degradation mechanism is stated, at the same time, the degradation kinetics of erythromycin A when [SCN]- exist in acid solution was also described by equation rA=1.93×10^4CAC[H]＋^1.59, which is found to be in line . with the experimental results. Compared with the result that w^thout [SCN]-, a conclumon that degradation rate of erythromycin A is droped by [SCN]-.