文献类型：期刊文献

英文题名：Leap-Type Response of Redox/Photo-Active Lanthanide-Based Metal-Organic Frameworks for Early and Accurate Screening of Prostate Cancer

作者：Ge, Kaiming[1];Chen, Guoli[1];Zhang, Dapeng[1];Hao, Ji-Na[1];Li, Yongsheng[1,2]

机构：[1]East China Univ Sci & Technol, Minist Educ, Lab Low Dimens Mat Chem, Frontier Sci Ctr Mat Biol & Dynam Chem,Key Lab Ult, Shanghai 200237, Peoples R China;[2]Shihezi Univ, Sch Chem & Chem Engn, State Key Lab Incubat Base Green Proc Chem Engn, Shihezi 832003, Peoples R China

年份：2024

卷号：63

期号：45

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20244417285886);WOS:【SCI-EXPANDED(收录号:WOS:001342098300046)】；

基金：This work was financially supported by the National Key Research and Development Program of China (Grant No. 2022YFC2403203), the National Natural Science Foundation of China (No. 52172279), Basic Research Program of Shanghai (21JC1406003), Shanghai Rising-Star Program (21QA1402200), the Natural Science Foundation of Shanghai Municipality (21ZR1416600), Leading Talents in Shanghai in 2018, and the Higher Education Discipline Innovation Project (B14018).

语种：英文

外文关键词：Luminescent Biosensors; Lanthanide Metal-Organic Frameworks; Defects; Leap-Type Response; Tumor Markers

摘要：The development of high-accuracy technologies to distinguish the quite tiny concentration change of tumor markers between negative and positive is of vital significance for early screening and diagnosis of cancers, but is still a great challenge for the conventional biosensors because of their "gradual" detection mode. Herein, a unique "leap-type" responsive lanthanide MOF-based biosensor (designated as Tb-CeMOF-X) with defect-mediated redox-/photo-activities is developed for precisely identifying acid phosphatase (ACP), an early pathological marker of prostate cancer (PCa) in serum. The engineered Tb-CeMOF-X probe achieves a bursting switch-on luminescence at the critical concentration of ACP (9 U & sdot; L-1), while keeping silent below this threshold, undergoing a qualitative signal change from "zero" to "one" between negative and positive indicators and thus significantly improving the identification precision. Significantly, such "leap-type" response performance can be further edited and amplified by rational defect engineering in the crystal structure to improve the accessibility of active centers, consequently maximizing the detection sensitivity toward ACP in the complex biological media. This study proposes the first paradigm for the development of "leap-type" biosensors with ultra-sensitive differentiation capability between negative and positive, and provides a potentially valuable tool for early and accurate screening of PCa.