文献类型：期刊文献

英文题名：N, N-Dicarboxymethyl hydrazine: an old but neglected reagent for chemoselective derivatization of carbonyl compounds

作者：Zhen, Maomin[1];Peng, Yanqing[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2016

卷号：14

期号：13

起止页码：3443

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20161402202880);WOS:【SCI-EXPANDED(收录号:WOS:000372795900013)，CCR-EXPANDED(收录号:WOS:000372795900013)】；

基金：Financial support for this work from the National Key Technology R&D Program (2011BAE06B05) is gratefully acknowledged.

语种：英文

外文关键词：Ketones - Aldehydes

摘要：N, N-Dicarboxymethyl hydrazine (DCMH) was found to be a chemoselective derivatization reagent of carbonyl compounds and its potential applications in organic synthesis was investigated for the first time. DCMH could be employed as a chemoselective protective reagent of aldehydes and gave the parent aldehydes in satisfactory yields. In proof-of-concept systems, DCMH could play the role of a scavenger to remove aldehydes in the presence of ketones. It was also used as a tagging reagent in the selective isolation of aldehyde from the complex mixture.