文献类型：期刊文献

中文题名：肝素化碳酸酯共聚物作为可降解药物支架涂层的应用

英文题名：Heparin-Immobilized Copolymer of Trimethylene Carbonate and Lactide as a Biodegradable Coating for Drug Eluting Stents

作者：饶炬[1];龚飞荣[1];陈建定[1];程树军[1]

机构：[1]华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海200237

年份：2009

卷号：43

期号：7

起止页码：1076

中文期刊名：上海交通大学学报

外文期刊名：Journal of Shanghai Jiaotong University

收录：CSTPCD;;EI(收录号：20093612285512);Scopus;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家高技术研究发展计划(863)项目(2007AA02Z450)

语种：中文

中文关键词：肝素;生物可降解;支架

外文关键词：heparin; biodegradable; stent

摘要：通过5-甲基-5-苄氧羰基-三亚甲基碳酸酯(MBC)和L-丙交酯(LLA)开环共聚,合成了完全生物可降解的乳酸——功能化碳酸酯的共聚物(PLM).PLM侧链苄基在Pa(OH)2、H2条件下脱除后,得到侧链含有羧基的聚合物(d-PLM).d-PLM膜表面经1-乙基-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐(WSC)活化后接枝肝素分子,得到肝素化乳酸——碳酸酯共聚物(Hep-PLM).经测定,Hep-PLM膜表面肝素含量达到6.33μg/cm2,亲水性较聚左旋丙交酯(PLLA)有明显提高.支架体外细胞培养试验显示,Hep-PLM具有良好的生物相容性.动物实验结果表明,Hep-PLM作为支架涂层材料对血管壁的炎性刺激明显低于PLLA,有望成为一种理想的生物可降解支架涂层材料.
Biodegradable polymer including L-lactide （LLA） and 5-methyl-5-benzyloxycarbonate-l,3-diox- an-2 -one （MBC） was synthesized by ring-opening polymerization. The polymer was deprotected under hy： drogen atmosphere using Pd（OH）2/C as a catalyst. Heparin was conjugated to the surface of the deprotected polymer film activated by WSC. The surface exposed heparin content associated was measured to be 6.33μg/cm2. The cell culture results show good biocompatibility of the heparin immobilized material and this novel polymer can be applied as a blood biocompatible and biodegradable coating material for coronary stents with lower inflammation formation and higher hydrophilicity than polylactide. This strategy may reduce implant-associated adverse responses and be a better approach for vascular tissue engineering applications.