文献类型：期刊文献

英文题名：Tricyano-Methylene-Pyridine Based High-Performance Aggregation-Induced Emission Photosensitizer for Imaging and Photodynamic Therapy

作者：Wu, Xupeng[1];Zhu, Zhirong[1];Liu, Zhenxing[1];Li, Xiangyu[1];Zhou, Tijian[1];Zhao, Xiaolei[2];Wang, Yuwei[1];Shi, Yiqi[1];Yu, Qianqian[1];Zhu, Wei-Hong[1];Wang, Qi[1]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr,Joint, Frontiers Sci Ctr Materiobiol & Dynam Chem,Inst F, Sch Chem & Mol Engn,Shanghai Key Lab Funct Mat Ch, Shanghai 200237, Peoples R China;[2]Changzhou Inst Technol, Res Ctr Resources & Environm, Sch Chem Engn & Mat, Changzhou 213032, Peoples R China

年份：2022

卷号：27

期号：22

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000887377800001)】；

基金：This work was supported by the NSFC/China (22222803, 91959202, and 21974047), the National Key Research and Development Program of China (2021YFA0910000), and the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03).

语种：英文

外文关键词：aggregation-induced emission; photosensitizer; ROS generation; bioimaging

摘要：Photosensitizers equipped with high reactive oxygen species (ROS) generation capability and bright emission are essential for accurate tumor imaging and precise photodynamic therapy (PDT). However, traditional aggregation-caused quenching (ACQ) photosensitizers cannot simultaneously produce desirable ROS and bright fluorescence, resulting in poor image-guided therapy effect. Herein, we report an aggregation-induced emission (AIE) photosensitizer TCM-Ph with a strong donor-pi-acceptor (D-pi-A) structure, which greatly separates the HOMO-LUMO distribution and reduces the Delta E-ST, thereby increasing the number of triplet excitons and producing more ROS. The AIE photosensitizer TCM-Ph has bright near-infrared emission, as well as a higher ROS generation capacity than the commercial photosensitizers Bengal Rose (RB) and Chlorine e6 (Ce6), and can effectively eliminate cancer cells under image guidance. Therefore, the AIE photosensitizer TCM-Ph has great potential to replace the commercial photosensitizers.