文献类型：期刊文献

英文题名：Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2

作者：Li, Na[1,2];Xiao, Lihua[2];Cama, Vitaliano A.[2];Ortega, Ynes[3];Gilman, Robert H.[4];Guo, Meijin[1];Feng, Yaoyu[1]

机构：[1]E China Univ Sci & Technol, Shanghai 200237, Peoples R China;[2]Ctr Dis Control & Prevent, Atlanta, GA USA;[3]Univ Georgia, Griffin, GA USA;[4]Johns Hopkins Univ, Baltimore, MD USA

年份：2013

卷号：19

期号：10

起止页码：1573

外文期刊名：EMERGING INFECTIOUS DISEASES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000328173900003)】；

基金：This study was supported in part by the National Natural Science Foundation of China (grants 31110103901 and 31229005), the National Basic Research Program of China (973 project no. 2011CB200903), the National Institutes of Health (grants 5P01AI051976 and 5R21AI059661), the US Department of Agriculture-Cooperative State Research, Education, and Extension Service (grant 2001-51110-11340), and Fundamental Research Funds for the Central Universities, China.

语种：英文

摘要：Little is known :about the emergence and spread of virulent subtypes of Cryptosporidium hominis, the predominant species responsible for human cryptosporidiosis. We conducted sequence analyses of 32 genetic loci of 53 C. hominis specimens isolated from a longitudinally followed cohort of children living in a small community. We identified by linkage disequilibrium and recombination analyses only limited genetic recombination, which occurred exclusively within the 60-kDa glycoprotein gene subtype IbA10G2, a predominant subtype for outbreaks in industrialized nations and a virulent subtype in the study community. Intensive transmission of virulent subtype IbA10G2 in the study area might have resulted in genetic recombination with other subtypes. Moreover, we identified selection for IbA10G2 at a 129-kb region around the 60-kDa glycoprotein gene in chromosome 6. These findings improve our understanding of the origin and evolution of C. hominis subtypes and the spread of virulent subtypes.