文献类型：期刊文献

中文题名：协同催化模式在金属铱催化不对称烯丙基取代反应中的应用研究进展

英文题名：Progress in Iridium-Catalyzed Asymmetric Allylic Substitution Reactions via Synergetic Catalysis

作者：田飞[1];张键[1];杨武林[1];邓卫平[1]

机构：[1]华东理工大学药学院,上海市新药设计重点实验室,上海200237

年份：2020

卷号：40

期号：10

起止页码：3262

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000598959400019)】；北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：Project supported by the National Natural Science Foundation of China (Nos. 21772038, 21901072), the Fundamental Research Funds for the Central Universities (No. 222201814048) and the Shanghai Sailing Program (No. 18YF140560).

语种：中文

中文关键词：不对称催化;烯丙基取代反应;铱催化剂;协同催化

外文关键词：asymmetric catalysis;allylic substitution reaction;iridium catalyst;synergetic catalysis

摘要：铱催化不对称烯丙基取代反应因其特殊的支链区域选择性和优秀的对映选择性已成为合成手性化合物的重要方法之一.采用铱/其他催化剂(有机小分子、过渡金属)协同催化体系能进一步拓宽亲核试剂的类型,并且通过对两种催化剂的调控有可能提高反应的对映选择性,甚至实现多手性中心产物的立体发散性合成.综述了金属铱与有机小分子或其他过渡金属协同催化的不对称烯丙基化反应研究进展.按照催化剂的类型(有机胺催化剂、相转移催化剂、布朗斯特酸、路易斯碱、过渡金属)对这些反应进行了梳理和总结,同时对代表性反应的机理以及该领域仍然存在的问题与未来发展进行了简单阐述.
Iridium-catalyzed asymmetric allylic substitution reaction has become one of the most important methods for the synthesis of chiral compounds due to its exceptional branched regioselectivity and excellent enantioselectivity.The scope of nucleophiles will be further expanded by synergetic catalysis system of iridium and other catalysts(organocatalysts,other transition metal catalysts).Besides,it is possible to improve the enantioselectivity of the reaction and even realize the stereodivergent synthesis of the products with multiple stereocenters.The progress in the field of catalytic asymmetric allylic substitutions through synergetic iridium and organocatalysis or other transition metal catalysis is summarized.These reactions are classified according to the types of catalysts(aminocatalyst,phase transfer catalyst,Br?nsted acid,Lewis base,transition metal).Meanwhile,the mechanism of representative reactions,the existing problems and the prospects in this area are briefly described.