文献类型：期刊文献

英文题名：Copper-catalysed radical cascade reaction of N-(2-oxo-2-phenylethyl) substituted 2-pyridones with styrene to access 1,6-carboannulated 2-pyridone scaffolds

作者：Jin, Shengkui[1];Hao, Liqiang[1];Li, Cunneng[3];Liu, Xian[1];Yu, Xiao[1];Mao, Jiaqian[1];Ding, Dong[2];Ji, Yafei[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Chongqing Bosen Pharmaceut Co Ltd, Fuan Pharmaceut Grp, Huanan Yi Rd, Chongqing 401254, Peoples R China;[3]Qilu Inst Technol, Coll Civil Engn, Jinan 250200, Peoples R China

年份：2025

卷号：23

期号：8

起止页码：1814

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20250417740262);WOS:【SCI-EXPANDED(收录号:WOS:001395601500001)，CCR-EXPANDED(收录号:WOS:001395601500001)】；

基金：We gratefully thank the National Natural Science Foundation of China (project no. 21676088) for financial support.

语种：英文

外文关键词：Catalysis - Free radical reactions - Pyridine - Reaction kinetics - Scaffolds - Substitution reactions

摘要：Herein, we present that treating N-(2-oxo-2-phenylethyl) substituted 2-pyridones with styrenes in DMSO/H2O at 120 degrees C affords 1,6-carboannulated 2-pyridone scaffolds with up to 79% yield. This protocol provides a simple and efficient method for obtaining complicated bicyclic 2-pyridones through a radical cascade reaction. Additionally, we have successfully synthesized 27 target compounds, which confirms the practicality and wide applicability of the proposed reaction.