文献类型：期刊文献

英文题名：Host defense peptide mimicking poly--peptides with fast, potent and broad spectrum antibacterial activities

作者：Zhang, Qiang[1];Ma, Pengcheng[1];Xie, Jiayang[1];Zhang, Si[1];Xiao, Ximian[1];Qiao, Zhongqian[1];Shao, Ning[1];Zhou, Min[1];Zhang, Wenjing[1];Dai, Chengzhi[1];Qian, Yuxin[1];Qi, Fan[1];Liu, Runhui[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Key Lab Ultrafine Mat, Res Ctr Biomed Mat,Minist Educ, Shanghai 200237, Peoples R China

年份：2019

卷号：7

期号：5

起止页码：2144

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20191806858261);WOS:【SCI-EXPANDED(收录号:WOS:000466769000030)】；

基金：This research was supported by the National Natural Science Foundation of China (No. 21574038, 21774031, 21861162010), the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), the National Key Research and Development Program of China (2016YFC1100401), the Natural Science Foundation of Shanghai (18ZR1410300), the "Eastern Scholar Professorship" from Shanghai local government (TP2014034), the national special fund for the State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities (22221818014). The authors also thank the Research Center of Analysis and Test of the East China University of Science and Technology for its help in characterization.

语种：英文

外文关键词：Antibiotics - Bacteria - Mammals - Antimicrobial agents - Network security

摘要：Microbial infections have always been serious challenges to human health considering that antibiotics almost inevitably induce microbial resistance. Therefore, it is urgent to develop a new antibacterial agent that is active against drug-resistant bacteria and is less susceptible to microbial resistance. In this work, a series of host defense peptide (HDP) mimicking antibacterial poly--peptides were synthesized, characterized and evaluated for their biological activities. The best poly--peptide within this study (20:80 Bu:DM) displays potent and broad spectrum antibacterial activity against antibiotic-resistant super bugs and low toxicity toward mammalian cells. Moreover, these poly--peptides are bactericidal and kill bacteria very fast within 5 min. An antimicrobial resistance test demonstrated that bacteria develop no resistance toward the selected poly--peptides even over 1000 generations. Our studies demonstrate that random copolymers of heterochiral poly--peptides, without the need for defined secondary structures, can mimic the antimicrobial HDP. These results imply the potential application of these poly--peptides as new antimicrobial agents to tackle drug resistant antimicrobial infections.