文献类型：期刊文献

英文题名：Radio frequency plasma polymers of n-butyl methacrylate and their controlled drug release characteristics. I. Effect of the oxygen gas

作者：Yuan, Yuan[1]; Liu, Changsheng[1]; Zhang, Yuan[1]; Yin, Min[1]; Shi, Chao-ou[2]

机构：[1] Engineering Research Center for Biomedical Materials, Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; [2] Center of Analysis and Research, East China University of Science and Technology, Shanghai, 200237, China

年份：2007

卷号：201

期号：15

起止页码：6861

外文期刊名：Surface and Coatings Technology

收录：EI(收录号：20071010468081)

语种：英文

外文关键词：Controlled drug delivery - Hydrophilicity - Organic coatings - Oxygen - Plasma applications - Structure (composition) - Surface properties

摘要：The effect of oxygen gas on the chemical structure, surface property and controlled drug release characteristics of radio frequency (RF) plasma poly-n-butyl methacrylate (PPBMA) thin films was investigated. The ATR-FTIR and XPS spectra of the resultant PPBMA films showed relatively higher concentration of C-H, C-C and C{double bond, long}C groups, but less intense peaks of C{double bond, long}O and C-O functionalities, which imply that the oxygen gas had no significant influence on the chemical structure of the plasma films. Results of the SEM experiment revealed that a dome-like structure was observed in the case of deposition without oxygen, but in the case of deposition with oxygen, a smooth and dense surface was produced. Moreover, the hydrophilicity of PPBMA obtained from the deposition with oxygen was higher than that without oxygen. Drug release from PPBMA deposition coating without oxygen had biphasic patterns, a fast release followed by a slow release, but the one with oxygen exhibited a slow Higuchi release. ? 2006 Elsevier B.V. All rights reserved.