文献类型：期刊文献

英文题名：Exploration of the generation, maintenance, and regulation mechanisms of slow-wave oscillations based on a thalamocortical model

作者：Wang, Shu[1];Xu, Xuying[1,2];Wang, Yihong[1,2];Pan, Xiaochuan[1,2];Du, Ying[1,2];Wang, Rubin[1]

机构：[1]East China Univ Sci & Technol, Inst Cognit Neurodyanm, Sch Math, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Ctr Intelligent Comp, Sch Math, Shanghai 200237, Peoples R China

年份：2025

卷号：113

期号：19

起止页码：26631

外文期刊名：NONLINEAR DYNAMICS

收录：;EI(收录号：20252418589252);WOS:【SCI-EXPANDED(收录号:WOS:001580598300021)】；

基金：This work was supported by the National Natural Science Foundation of China (Nos. 12272136, 12172132 and 12472054) and Science and Technology Commission of Shanghai Municipality (No. 24JS2810400).

语种：英文

外文关键词：Sleep; Slow-wave Oscillations; Thalamocortical Model; N3 Stage; Spontaneous Postsynaptic Excitatory Potentials

摘要：Sleep is crucial for the formation of long-term memory in humans and animals. Experimental studies have shown that during different sleep stages, the electroencephalogram signals exhibit a specific rhythmic pattern. In the N3 stage of deep sleep, the hallmark of electroencephalogram is the large amplitude and slow frequency (0.2 ~4Hz) fluctuations called slow-wave oscillations generated by the cortex. They are characterized by spontaneous and periodic neural activity patterns alternating between active states and silent states named up and down states, respectively. Slow-wave oscillations play a crucial role in memory consolidation and synaptic plasticity during sleep. Their generation is thought to relate to the interaction between cortical and thalamic circuits. However, the exact mechanisms underlying their generation and maintenance remain unclear. Therefore, in this paper, we simulated the spontaneous slow-wave oscillations generated in the cerebral cortex during the N3 sleep stage based on a class of thalamocortical network models, and discussed the mechanisms of their generation, maintenance, and regulation at the molecular level. The results indicate that spontaneous miniature postsynaptic excitatory potentials are responsible for generating and maintaining slow-wave oscillations and a decrease in spontaneous activity prolongs the down state of slow-wave oscillations. While the enhancement of excitatory synaptic currents modulated by Acetylcholine in the cortex prolongs the up state of slow-wave oscillations. Additionally, an increase in the maximal persistent sodium conductance of cortical neurons prolongs the up state, thereby modulating the slow oscillation rhythm. This work provides model simulation support for the generation, maintenance, and regulation of slow-wave oscillations by exploring various external influence parameters. It may be significant for enhancing our understanding the mechanisms underlying slow-wave oscillations and further investigating their role in memory consolidation, and also offers some theoretical support for treatment directions in related sleep disorders.