文献类型：期刊文献

英文题名：Spectrometric study on the hydrophobic hydration in the formation of Tween-60 micelles with curcumin

作者：Zheng, Yuqing[1];Bao, Zhoujie[1];Fan, Yaxun[2,3];Wang, Xiaoyong[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci BNLMS, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China;[3]Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China

年份：2023

卷号：370

外文期刊名：JOURNAL OF MOLECULAR LIQUIDS

收录：;EI(收录号：20225113272160);WOS:【SCI-EXPANDED(收录号:WOS:000906275800001)】；

基金：This work is supported by the National Natural Science Founda- tion of China (Grant 22273022) .

语种：英文

外文关键词：Hydrophobic hydration; Surfactant; Tween-60; curcumin complexes; Hydrogen bonding; Hydrophobic interaction

摘要：The hydrophobic hydration in the formation of Tween-60 micelles upon entrapping bioactive curcumin has been observed and studied. The atypically increased values of pyrene polarity index suggest that Tween-60/curcumin complexes with bigger bulk hydrophobic part have stronger hydrophobic hydration than curcumin alone. The low-field shifts of water proton by 1H NMR method can also confirm the formation of stronger hydrogen bond network of water molecules surrounding Tween-60/curcumin complexes. However, the hydrophobic aggregation of surfactant alkyl chains into Tween-60 premicelles and micelles may destroy the hydrophobic hydration of Tween-60/curcumin complexes, which is indicated by the decreasing change of pyrene polarity index with increasing Tween-60 concentration. The fluorescence anisotropy of curcumin is observed to have sharply decreased values for Tween-60/curcumin complexes, which correlates positively with the hydrogen bonding strength of water molecules around curcumin. The fluorescence anisotropy, fluorescence spectroscopy and stability of curcumin cooperatively suggest that there is gradually weakened contact of curcumin with water in the order of curcumin alone, Tween-60/curcumin complexes, curcumin with Tween-60 premicelles and micelles. This work demonstrates that the hydrophobic hydration plays an important role in the entrapment of curcumin from a polar medium of water to surfactant micelles.