文献类型：期刊文献

英文题名：Silver-Mediated anti-Markovnikov and Markovnikov-Selective Hydrotrifluoromethylthiolation of Terminal Alkynes

作者：Wu, Wei[1];Dai, Wenpeng[1];Ji, Xinfei[1];Cao, Song[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2016

卷号：18

期号：12

起止页码：2918

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000378303400033)，CCR-EXPANDED(收录号:WOS:000378303400033)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Nos. 21472043 and 21272070).

语种：英文

摘要：The first example of direct hydrotrifluoromethylthiolation of terminal alkynes in the presence of AgSCF3 and K2S2O8 was established for the synthesis of a variety of vinyl trifluoromethyl thioethers. The anti-Markovnikov and Markovnikov adducts were obtained in moderate to good yields via two different reaction systems. Studies to probe the mechanism of the anti-Markovnikov addition reactions including the radical trapping experiments, kinetic isotope effect experiments, and deuterated experiments for determination of H-sources were conducted.