文献类型：期刊文献

英文题名：Dynamic Kinetic Resolution of Biaryl Lactones via a Chiral Bifunctional Amine Thiourea-Catalyzed Highly Atropoenantioselective Transesterification

作者：Yu, Chenguang[1];Huang, He[1];Li, Xiangmin[1,2,3];Zhang, Yueteng[1];Wang, Wei[1,2,3]

机构：[1]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai 200237, Peoples R China

年份：2016

卷号：138

期号：22

起止页码：6956

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20162502526071);WOS:【SCI-EXPANDED(收录号:WOS:000377643300013)，CCR-EXPANDED(收录号:WOS:000377643300013)】；

基金：Financial support of this research from the National Science Foundation of China (21372073 and 21572055) and the NSF (CHE-1565085) is gratefully acknowledged.

语种：英文

外文关键词：Enantioselectivity - Transesterification - Esters

摘要：A solution to the unmet synthetic challenge of achieving highly atropo-enantioselective transestetification of Bringmann's lactones has been realized, employing a chiral bifunctional amine thiourea as promoter. The synergistic activation of the lactones,and alcohols/phenols by the respective thiourea and amine groups-is crucial for achieving the highly enantioselective, high-yielding dynamic kinetic resolution process: This protocol gives highly optically pure, axially chiral biaryl compounds with a broad substrate scope under mild reaction conditions.