文献类型：期刊文献

英文题名：Surface modification by poly(ethylene glycol) with different end-grafted groups: Experimental and theoretical study

作者：Han, Xia[1,2];Yuan, Zhaobin[1,2];Niu, Yapeng[3];Chen, Xueqian[4];Liu, Honglai[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]China Tobacco Henan Ind Co Ltd, Technol Ctr, Zhengzhou 450000, Peoples R China;[4]East China Univ Sci & Technol, Sch Sci, Shanghai 200237, Peoples R China

年份：2021

卷号：16

期号：2

外文期刊名：BIOINTERPHASES

收录：;EI(收录号：20211210124223);WOS:【SCI-EXPANDED(收录号:WOS:000629321800001)】；

基金：Financial support for this work was provided by the National Natural Science Foundation of China (NNSFC) (Nos. 21878075 and 21878077) and the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (No. 51621002).

语种：英文

外文关键词：Iron oxides - Binding energy - Ethylene glycol - Calculations - Polyols - Hydroxylation - Silicon compounds - Silicon wafers - Gold - Polyethylene glycols - Substrates - Wetting

摘要：Dihydroxyphenylalanine (DOPA) is extensively reported to be a surface-independent anchor molecule in bioadhesive surface modification and antifouling biomaterial fabrication. However, the mechanisms of DOPA adsorption on versatile substrates and the comparison between experimental results and theoretical results are less addressed. We report the adsorption of DOPA anchored monomethoxy poly(ethylene glycol) (DOPA-mPEG) on substrates and surface wettability as well as antifouling property in comparison with thiol and hydroxyl anchored mPEG (mPEG-SH and mPEG-OH). Gold and hydroxylated silicon were used as model substrates to study the adsorptions of mPEGs. The experimental results showed that the DOPA-mPEG showed higher affinity to both gold and silicon wafers, and the DOPA-mPEG modified surfaces had higher resistance to protein adsorption than those of mPEG-SH and mPEG-OH. It is revealed that the surface wettability is primary for surface fouling, while polymer flexibility is the secondary parameter. We present ab initio calculations of the adsorption of mEGs with different end-functionalities on Au and hydroxylated silicon wafer (Si-OH), where the binding energies are obtained. It is established that monomethoxy ethylene glycol (mEG) with DOPA terminal DOPA-mEG is clearly favored for the adsorption with both gold and Si-OH surfaces due to the bidentate Au-O interactions and the bidentate O-H bond interactions, in agreement with experimental evidence.