文献类型：期刊文献

英文题名：Multi-responsive hydrogels with UCST- and LCST-induced shrinking and controlled release behaviors of rhodamine B

作者：Sun, Hui;Chen, Jing;Han, Xia[1];Liu, Honglai

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2018

卷号：82

起止页码：284

外文期刊名：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

收录：;EI(收录号：20173704155106);WOS:【SCI-EXPANDED(收录号:WOS:000414886400031)】；

基金：The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (nos. 21376073 and 91534103), the 111 Project of the Ministry of Education of China (no. B08021), and Fundamental Research Funds for the Central Universities of China.

语种：英文

外文关键词：Controlled drug delivery - Sulfur compounds - Targeted drug delivery - Diffusion - Hydrogels - Monomers

摘要：By using a disulfide-functionalized crosslinker, a pH- and thermo-responsive 2-(dimethylamino) ethyl methacrylate (DMAEMA) monomer and a zwitterionic sulfobetaine methacrylate (SBMA) monomer were conjugated to fabricate a multi-responsive P(DMAEMA-SS-SBMA) copolymeric hydrogel. Apparent UCST and LCST volume transitions were observed in the P(DMAEMA-SS-SBMA) hydrogels with equivalent weight fractions of monomers. Different pore size and response sensitivity of shrunken structures below UCST and above LCST were visualized by SEM images. The hydrogel exhibited a highly swollen state with a swelling ratio of 17.8 and a pore size of 106 mu m at 45 degrees C, they deswelled unequally at 5 degrees C with a compact surface with pore size of 30 mu m and a loose bulk with pore size of 83 mu m, while they deswelled uniformly at 65 degrees C with dense shrunken structure with small pore size of 12 mu m. The dual-thermoresponsive hydrogel was promising in controlled drug release. The initial drug release was predominantly controlled by diffusion, and the long-term release was influenced by the swelling ratio. Below UCST, the relatively hydrophilic shrunken structure and slow diffusion had a synergistic effect on the sustained release. Above LCST, the fast diffusion and the rapid "off" effect of hydrophobic skin layer resulted in a burst release. Additionally, pH-tunable swelling and redox-sensitive degradation were also observed.