文献类型：期刊文献

中文题名：线性-树枝状共聚物载药微球的制备、表征及体外释放

英文题名：Preparation,Characterization and Release Behavior of Drug-Loaded Microparticles by Linear-Dendritic Diblock Copolymer

作者：杨李影[1];郭睿[2];戎宗明[1]

机构：[1]华东理工大学化学与分子工程学院,上海200237;[2]巴斯夫上海涂料有限公司,上海201108

年份：2017

卷号：43

期号：1

起止页码：50

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；CSCD:【CSCD_E2017_2018】；

语种：中文

中文关键词：线性-树枝状共聚物;生物可降解;载药微球;体外释放;雷帕霉素

外文关键词：linear-dendritic diblock copolymer; biodegradable; drug-loaded microparticles; drug in vitro release; rapamycin

摘要：以自制的生物可降解线性-树枝状两嵌段两亲共聚物材料为药物载体,采用透析法制备了雷帕霉素载药微球。通过扫描电子显微镜(SEM)、动态光散射仪(DLS)、紫外分光光度计对雷帕霉素载药微球的表面形貌、粒径分布、载药量及释放行为进行了研究。结果表明:载药微球的载药量和包封率分别可达到40%和90%以上,与哑铃型三嵌段两亲共聚物载药微球相当,但平均粒径大幅降低(粒径约300nm),同样具有显著的缓释作用。
The rapamycin-loaded spherical microparticle based on biodegradable linear-dendritic diblock copolymer is prepared by dialysis method. Scanning electronic microscope（SEM） , dynamic light scattering （DLS） and UV spectrophotometer were used to investigate morphology, size and in vitro release behavior of these particles. The results showed that the drug content and encapsulation efficiency of drug-loaded microparticles prepared by diblock copolymer, as well as those prepared by dumbbell-shaped triblock copolymer, could be more than 40% and 90%, respectively. Meanwhile, the mean size of those microparticles reduced significantly and it showed an obvious sustained release as well.