文献类型：期刊文献

英文题名：Improving the physicochemical properties of bicalutamide by complex formation with bovine serum albumin

作者：Yang, Congbin[1];Di, Peiwen[2];Fu, JinPing[1];Xiong, Hui[1];Jing, Qiufang[1,2];Ren, Guobin[1];Tang, Yun[2];Zheng, Wenyun[2];Liu, Guixia[2];Ren, Fuzheng[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Lab Pharmaceut Crystal Engn & Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：106

起止页码：381

外文期刊名：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000406988600039)】；

基金：The authors gratefully acknowledge financial support from the Shanghai Committee of Science and Technology (under Grant no. 14DZ1930802) and the National Natural Science Foundation of China (under Grant No. 21576080).

语种：英文

外文关键词：Bovine serum albumin; Bicalutamide; Anti-solvent precipitation; Interaction; Molecular docking

摘要：Bicalutamide-bovine serum albumin (Bic-BSA) complexes were prepared by anti-solvent precipitation. Bovine serum albumin (BSA) was used as a stabilizer for particle growth. The physicochemical properties of Bic-BSA were analyzed by scanning electron microscopy, X-ray powder diffraction and differential scanning calorimetry. The interaction between Bic and BSA was characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, fluorescence spectroscopy and molecular docking. The particle size could be easily reduced to 1-10 mu m with a good lognormal distribution. The Bic-BSA complexes exhibited nonporous spherical morphology with a uniformly plicated surface. Moreover, the crystal form and thermostability of Bic were altered in the presence of BSA. Bic was found to make hydrogen bonding and hydrophobic interactions with BSA by spectroscopic studies and molecular docking. Results from the Ven't Hoff equation and binding free energy calculations indicated that the improvement of physicochemical properties was the consequence of a variety of interactions in the Bic-BSA system. Bic-BSA tablets showed significantly enhanced dissolution. It was concluded that BSA plays an important role in improving the physicochemical properties of Bic due to strong multiple interactions between Bic and BSA.