文献类型：期刊文献

中文题名：环氧虫啶-二甲基-β-环糊精包合物的制备及表征

英文题名：Preparation and Characterization of the Inclusion Compound of Cycloxaprid with Dimethyl-β-cyclodextrin

作者：王云[1];谭文娟[1];冯舒[2];张芝平[3];高峰[1,2,4]

机构：[1]华东理工大学上海市功能性材料化学重点实验室,上海200237;[2]华东理工大学上海市新药设计重点实验室,上海200237;[3]上海生农生化制品有限公司,上海201102;[4]华东理工大学药学院药剂教研组,上海200237

年份：2016

卷号：55

期号：5

起止页码：331

中文期刊名：农药

外文期刊名：Agrochemicals

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD_E2015_2016】；

基金：上海市"联盟计划"资助项目(LM201417)

语种：中文

中文关键词：环氧虫啶;二甲基-β-环糊精;包合物;溶解度

外文关键词：cycloxaprid; dimethyl-β-cyclodextrin; inclusion complex; solubility

摘要：[目的]制备难溶性药物环氧虫啶的二甲基-β-环糊精(DM-β-CD)包合物,并对其表征。[方法]采用溶液搅拌法制备环氧虫啶-DM-β-CD包合物,运用红外光谱法、X-射线衍射法和扫描电镜法对其进行表征,相溶解度法研究环氧虫啶和DM-β-CD的包合特性。[结果]DM-β-CD与环氧虫啶以1∶1的比例形成环氧虫啶-DM-β-CD包合物,其溶解度为(14.3±0.2)g/L。在水中放置24 h时,环氧虫啶及其包合物分别水解了62.1%和3.6%。[结论]DM-β-CD与环氧虫啶形成包合物,提高了环氧虫啶的水中溶解度和稳定性。
[Aims] The study aims to prepare and characterize inclusion complex of a water insoluble drug cycloxaprid with dimethyl-fl-cyclodextrin （DM-β-CD）. [Methods] The cycloxaprid-DM-fl-CD inclusion complex was prepared by the solution stirring method and characterized by means of infi＇ared spectroscopy, X-ray diffractometry and scanning electron microscope. In addition, the inclusion interaction between cycloxaprid and DM-β-CD was studied by phase solubility method. [Results] The results showed that the inclusion complex with a 1：1 stoichiometry of cycloxaprid and DM-fl-CD was formulated successfully. The solubility of cycloxaprid-DM-β-CD inclusion complexes was （14.3±0.2） g/L. After dissolving in water for 24 hours, the hydrolyzed amount of cycloxaprid and cycloxaprid-DM-β-CD was 62.1 and 3.6%, respectively. [Conclusions] The cycloxaprid can form to DM-fl-CD, thus improving the solubility and stability of cycloxaprid effectively.