文献类型：期刊文献

英文题名：Dual-responsive nanohybrid based on degradable silica-coated gold nanorods for triple-combination therapy for breast cancer

作者：Cheng, Di[1];Ji, Yuejia[1];Wang, Bin[1];Wang, Yuyu[1];Tang, Yao[1];Fu, Yun[1];Xu, Yufang[1];Qian, Xuhong[1];Zhu, Weiping[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2021

卷号：128

起止页码：435

外文期刊名：ACTA BIOMATERIALIA

收录：;EI(收录号：20215111338635);WOS:【SCI-EXPANDED(收录号:WOS:000663835700008)】；

基金：This work was supported by National Natural Science Foundation of China (Grants 21878088, 21476077), Key projects of Shanghai Science and Technology Commission (18DZ1112703).

语种：英文

外文关键词：Degradable organosilica; Gold nanorod; Multi-modal therapy; Tumor ablation

摘要：Multi-modal combination therapy has attracted great attention, owing to the unsatisfactory therapeutic efficacy of conventional chemotherapy. Mesoporous silica-coated gold nanorods possess great potential in photothermal therapy and drug delivery. In this work, we fabricate a dual-responsive nanohybrid for combination treatment of the malignant tumor. In this system, gold nanorods are coated with the degradable mesoporous silica, and the chemotherapy drug doxorubicin (DOX) and photosensitizer (IR820) are co-loaded inside the pores of the silica. The encapsulation of hyaluronic acid (HA) endow the nanohybrids with mammary carcinoma targeting ability and better biocompatibility, owning to CD44 + receptor overexpressed in some cancer cells. As-prepared nanohybrids exhibit high responsiveness to a high glutathione (GSH) level and degrade rapidly in the presence of hyaluronidase (HAase) and GSH after endocytosis by 4T1 cells, allowing the efficient release of loaded DOX and IR 820 in tumor sites. Interestingly, near-infrared (NIR) laser not only triggers the generation of reactive oxygen species, but also remarkable photothermal efficacy originating from GNRs. Therefore, upon the irradiation of 808 nm NIR light, the combinatorial photodynamic, photothermal and chemotherapy is achieved, accordingly leading to a highly efficient antitumor outcome in vitro and in vivo . This strategy provides an ideal approach to constructing multimodal cancer therapy system.