文献类型：期刊文献

英文题名：Copper Nanoclusters Anchored on Crumpled N-Doped MXene for Ultra-Sensitive Electrochemical Sensing

作者：Yang, Hanxue[1,2,3];Rong, Chao[1,2,3];Ge, Shundong[1,2,3];Wang, Tao[1,2,3];Zhang, Bowei[1,2,3];Xuan, Fu-Zhen[1,2,3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Intelligent Sensing & Detect Tech, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Pressure Syst & Safety, Minist Educ, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：25

期号：8

外文期刊名：SENSORS

收录：;EI(收录号：20251818327032);WOS:【SCI-EXPANDED(收录号:WOS:001476646200001)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant No. 52422505, No. 12274124), the Shanghai Pilot Program for Basic Research (Grant No. 22TQ1400100-6), the Fundamental Research Funds for the Central Universities, and the Innovative Research Group Project of the National Natural Science Foundation of China (Grant No. 52321002), the National Natural Science Foundation of China (Grant No. 62301314).

语种：英文

外文关键词：MXene; Cu nanoclusters; crumpled structure; dopamine; uric acid

摘要：Simultaneous detection of dopamine (DA) and uric acid (UA) is essential for diagnosing neurological and metabolic diseases but hindered by overlapping electrochemical signals. We present an ultrasensitive electrochemical sensor using copper nanoclusters anchored on nitrogen-doped crumpled Ti3C2Tx MXene (Cu-N/Ti3C2Tx). The engineered 3D crumpled architecture prevents MXene restacking, exposes active sites, and enhances ion transport, while Cu nanoclusters boost electrocatalytic activity via accelerated electron transfer. Structural analyses confirm uniform Cu dispersion (3.0 wt%), Ti-N bonding, and strain-induced wrinkles, synergistically improving conductivity. The sensor achieves exceptional sensitivity (1958.3 and 1152.7 mu AmM(-1)cm(-2) for DA/UA), ultralow detection limits (0.058 and 0.099 mu M for DA/UA), rapid response (<1.5 s), and interference resistance (e.g., ascorbic acid). Differential pulse voltammetry enables independent linear detection ranges (DA: 2-60 mu M; UA: 5-100 mu M) in biofluids, with 94.4% stability retention over 7 days. The designed sensor exhibits excellent capabilities for DA and UA detection. This work provides a novel design strategy for developing high-performance electrochemical sensors.