文献类型：期刊文献

英文题名：Construction and characterization of a temperature-responsive nanocarrier for imidacloprid based on mesoporous silica nanoparticles

作者：Yao, Pengji[1,2];Zou, Aihua[3];Tian, Zhenfen[1,2];Meng, Wenyan[1,2];Fang, Xialun[1,2];Wu, Tong[4];Cheng, Jiagao[4]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Appl Chem, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Shanghai Normal Univ, Coll Chem & Mat Sci, Shanghai 200234, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2021

卷号：198

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20205009599929);WOS:【SCI-EXPANDED(收录号:WOS:000620180800009)】；

基金：The present study was supported by grants from the National Natural Science Foundation of China (No. 21872051) and the National Key Research and Development Plan (No. 2017YFD0200306).

语种：英文

外文关键词：Nanopesticides; Temperature-responsive; Imidacloprid; MSNs; Bioactivity

摘要：Nanopesticides have great potential applications due to their stability enhancement, sustained release and target affinity. In this work, a temperature-responsive nanocarrier for imidacloprid (IMI) was constructed using mesoporous silica nanoparticles (MSNs) as the core and paraffin wax (PW) as the outer layer. IMI was loaded into MSNs by screening the drug/carrier mass ratios to obtain the optimized IMI/MSNs formulation with a high drug loading (27.47 %). IMI/MSNs were functionalized with octadecyltrimethoxysilane (C18TMS) and further coated with a temperature-responsive trigger (PW) through hydrophobic interactions. Thus, a temperature-responsive nanocarrier for IMI (PW/IMI/MSNs) was constructed. Fourier transforms infrared (FT-IR), thermogravimetric analysis (TGA) and N-2 adsorption-desorption isotherm measurements confirmed the successful loading of IMI into MSNs and the coating of PW on the surface of the IMI/MSNs. X-ray diffraction (XRD) and transmission electron microscopy (TEM) analyses indicated that PW/IMI/MSNs with diameters approximately 100 nm had an ordered hexagonal mesoporous structure with a surface coating of approximately 6 nm. In addition, an in vitro release experiment showed that PW/IMI/MSNs displayed a temperature-responsive sustained release property. Correspondingly, the bioactivity assay of the PW/IMI/MSNs showed that the insecticidal activity greatly increased with temperature. This formulation is expected to have potential applications in some high-temperature areas, such as Turpan in Xinjiang Province, for improving the utilization efficiency of IMI.