文献类型：期刊文献

英文题名：An Efficient Synthesis of 2-Aminofuran-3-carbonitriles via Cascade Stetter-γ-Ketonitrile Cyclization Reaction Catalyzed by N-Heterocyclic Carbene

作者：Liu, Peng[1];Lei, Min[1];Ma, Lei[1];Hu, Lihong[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China

年份：2011

期号：8

起止页码：1133

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000290206600017)，CCR-EXPANDED(收录号:WOS:000290206600017)】；

基金：This work was supported by the Chinese National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program' (Grants 2009ZX09301-001, 2009ZX09102-022), the National Natural Science Foundation of China (Grants 21002027, 90713046, 30772638 and 30925040) and the CAS Foundation (Grant KSCX2-YW-R-179).

语种：英文

外文关键词：N-heterocyclic carbenes (NHCs); umpolung; cascade reaction; Stetter reaction; 2-aminofuran

摘要：An efficient method for the synthesis of 4,5-disubstituted 2-aminofuran-3-carbonitriles via a cascade Stetter-gamma-ketonitrile cyclization reaction of aromatic aldehydes with acylidenemalononitriles, catalyzed by N-heterocyclic carbenes, has been developed. This procedure provides the corresponding products in moderate to high yields under mild conditions.