文献类型：期刊文献

英文题名：Conjugated Polymer Coupled with Nonconjugated Segments for NIR-II Fluorescence/NIR-II Photoacoustic Imaging-Guided NIR-II Photothermal Therapy

作者：Hu, Danni[1,2];Du, Xinlong[1,2];Qu, Fan[1,2];Yang, Zelan[1,2];Chen, Pengfei[1,2];Shen, Qingming[1,2];Miao, Han[3];Sun, Pengfei[1,2];Fan, Quli[1,2]

机构：[1]Nanjing Univ Posts & Telecommun, State Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China;[2]Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, Jiangsu Key Lab Biosensors, Nanjing 210023, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2023

卷号：5

期号：10

起止页码：8712

外文期刊名：ACS APPLIED POLYMER MATERIALS

收录：;EI(收录号：20234414980951);WOS:【SCI-EXPANDED(收录号:WOS:001071971000001)】；

基金：We are grateful for the financial support from the National Natural Science Foundation of China (grant nos. 22375102 and 52373142), the Natural Science Foundation of Jiangsu Province (grant nos. BK20201380 and BK20221326), and the Natural Science Foundation of Jiangsu Higher Education Institutions (grant no. 20KJA430012). The authors are grateful for the financial support provided by the Shanghai Pujiang Program (grant no. 21PJ1402100) and the Young Scientists Fund of the National Natural Science Foundation of China (grant no. 52203258).

语种：英文

外文关键词：D-A-D molecule; NIR-II PA imaging; NIR-II photothermal; NIR-II FL imaging

摘要：Development of conjugated polymer-based water-soluble nanoparticles (NPs) for second near-infrared fluorescence (NIR-II FL, 1000-1700 nm) and NIR-II photoacoustic (PA) imaging-guided NIR-II photothermal therapy (PTT) is expected to gain favor in clinical anticancer applications. However, integrating these imaging and therapeutic functions into a single NIR-II absorption conjugated polymer BTC12 is a major challenge to accurately balance the nonradiative and radiative decay pathways. Herein, an NIR-II absorption conjugated polymer was designed and synthesized by coupling flexible nonconjugated segments into a polymer backbone to simultaneously achieve NIR-II FL, NIR-II PA imaging, and NIR-II PTT. The developed conjugated polymer-based water-soluble NPs (BTC12 NPs) showed satisfactory functionality with a promising photothermal conversion efficiency of 46.8%. An in vivo study demonstrated that BTC12 NPs can accurately acquire the tumor location and size via NIR-II FL/NIR-II PA imaging. Furthermore, BTC12 NPs showed marked antitumor efficacy by NIR-II PTT upon 1064 nm laser irradiation. This work provides a perspective for the design of multifunction conjugated polymers for NIR-II FL/NIR-II PA imaging-guided NIR-II PTT applications.