文献类型：期刊文献

英文题名：Differences in reward processing between putative cell types in primate prefrontal cortex

作者：Fan, Hongwei[1,2];Pan, Xiaochuan[3];Wang, Rubin[3];Sakagami, Masamichi[1]

机构：[1]Tamagawa Univ, Brain Sci Inst, Machida, Tokyo, Japan;[2]Oracle China Software Syst Co Ltd, Beijing, Peoples R China;[3]East China Univ Sci & Technol, Inst Cognit Neurodynam, Shanghai, Peoples R China

年份：2017

卷号：12

期号：12

外文期刊名：PLOS ONE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000418554900028)】；

基金：This work was supported by the Strategic Research Program for Brain Sciences from the Japan Agency for Medical Research and Development (AMED) to MS, a Grant-in-Aid for Scientific Research on Innovative Areas (4805) from MEXT of Japan to MS. It is supported by National Natural Science Foundation of China (No. 11232005, No. 11472104 to RW) and sponsored by Shanghai Pujiang Program (No. 13PJ1402000 to XP). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Oracle (China) Software Systems Co., Ltd. (Oracle China) is not a funder of our study. Oracle China provided support in the form of salaries for authors [HWF], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the author contributions section.

语种：英文

摘要：Single-unit studies in monkeys have demonstrated that neurons in the prefrontal cortex predict the reward type, reward amount or reward availability associated with a stimulus. To examine contributions of pyramidal cells and interneurons in reward processing, single-unit activity was extracellularly recorded in prefrontal cortices of four monkeys performing a reward prediction task. Based on their shapes of spike waveforms, prefrontal neurons were classified into broad-spike and narrow-spike units that represented putative pyramidal cells and interneurons, respectively. We mainly observed that narrow-spike neurons showed higher firing rates but less bursty discharges than did broad-spike neurons. Both narrow-spike and broad-spike cells selectively responded to the stimulus, reward and their interaction, and the proportions of each type of selective neurons were similar between the two cell classes. Moreover, the two types of cells displayed equal reliability of reward or stimulus discrimination. Furthermore, we found that broad-spike and narrow-spike cells showed distinct mechanisms for encoding reward or stimulus information. Broad-spike neurons raised their firing rate relative to the baseline rate to represent the preferred reward or stimulus information, whereas narrow-spike neurons inhibited their firing rate lower than the baseline rate to encode the non-preferred reward or stimulus information. Our results suggest that narrow-spike and broad-spike cells were equally involved in reward and stimulus processing in the prefrontal cortex. They utilized a binary strategy to complementarily represent reward or stimulus information, which was consistent with the task structure in which the monkeys were required to remember two reward conditions and two visual stimuli.