文献类型：期刊文献

中文题名：抗生素负载型二硫化钼-糖基苝酰亚胺自组装体系构建及抗菌研究

英文题名：Construction and Antibacterial Application of 2D MoS2-Glycoperylenediimide Antibiotic-Loading System

作者：吴棒[1];胡习乐[1];陈国荣[1]

机构：[1]华东理工大学结构可控先进功能材料及其制备教育部重点实验室,费林加诺贝尔奖科学家联合研究中心,上海200237

年份：2021

卷号：47

期号：2

起止页码：195

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD_E2021_2022】；

基金：国家传染病重点科技项目(2018ZX10732202);中国博士后科学基金(2018M630407)。

语种：中文

中文关键词：二硫化钼;苝酰亚胺;光动力治疗;载药;绿脓杆菌

外文关键词：MoS2;perylenediimide;photodynamic therapy;drug-loading;pseudomonas aeruginosa

摘要：引入半乳糖基或甘露糖基共价缀合的苝酰亚胺化合物,并将其通过π-π堆叠作用负载在片层二硫化钼表面,进一步包载抗生素头孢他啶构建了靶向细菌的治疗体系。利用具有光敏活性的苝酰亚胺母核及二硫化钼在光照下能够释放活性氧簇实现光动力治疗细菌的特点,达到了靶向细菌的光动力协同药物治疗效果。该自组装光动力载药治疗体系的构建大大减少了抗生素药物的使用量,降低了细菌耐药性,为临床性顽固细菌治疗提供了新的思路。
Bacterial infection has been one of the major health threats to modern human beings.Effective as they are,the traditional antibiotics are also easy to cause bacterial drug-resistance,thereby leading to the extensive development of advanced functional materials with photodynamic/photothermal and drug-loading properties.To endow the materials with targeting effects to improve the therapeutic efficiency,it is important to introduce a targeting moiety during the construction of antibacterial systems.Carbohydrates are commonly used as targeting agents,because they can not only target corresponding lectins on bacteria but also significantly enhance the biocompatibility of materials.Here,a galactose-conjugated perylenediimide was loaded onto 2D MoS2 platform throughπ-πstacking.Moreover,the antibiotic ceftazidime was encapsulated to form a Pseudomonas aeruginosa-targeted therapeutic system.Perylenediimide,as a photosensitizer,could produce reactive oxygen species upon light irradiation for photodynamic therapy,which further realized combinning chemo-and photodynamic therapy on Pseudomonas aeruginosa.This complexed system significantly reduces the dose of antibiotics,diminishes drug-resisting effects and provides new therapeutic insights for clinical-chronic bacteria.