文献类型：期刊文献

英文题名：Mixture of Nonionic/Ionic Surfactants for the Formulation of Nanostructured Lipid Carriers: Effects on Physical Properties

作者：Zhao, Shuangni[1,2];Yang, Xiaomin[1,2];Garamus, Vasil M.[3];Handge, Ulrich A.[5];Berengere, Luthringer[3];Zhao, Lin[4];Salamon, Gabriele[3];Willumeit, Regine[3];Zou, Aihua[1,2];Fan, Saijun[4]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Appl Chem, Shanghai 200237, Peoples R China;[3]Inst Mat Res, Helmholtz Zentrum Geesthacht, Ctr Mat & Coastal Res, D-21502 Geesthacht, Germany;[4]Soochow Univ, Sch Radiat Med & Protect, Coll Med, Suzhou 215123, Peoples R China;[5]Polymer Res Inst, Helmholtz Zentrum Geesthacht, Ctr Mat & Coastal Res, D-21502 Geesthacht, Germany

年份：2014

卷号：30

期号：23

起止页码：6920

外文期刊名：LANGMUIR

收录：;EI(收录号：20142617866010);WOS:【SCI-EXPANDED(收录号:WOS:000337644200035)】；

基金：Dr. Lihui Zhou is acknowledged for help during TEM measurements and Ivonne Ternes for DSC experiments. Aihua Zou gratefully acknowledges the support of this work by the Alexander von Humboldt Foundation. We gratefully acknowledge the support of this work by Chinese National Natural Science Foundation (201003047) and Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：High performance liquid chromatography - Targeted drug delivery - Antigen-antibody reactions - Mixtures - X ray scattering - Particle size - Controlled drug delivery - Dynamic light scattering - Scanning electron microscopy - Polydispersity - Emulsification - High resolution transmission electron microscopy - Nonionic surfactants

摘要：The objective of the present work was to investigate the effects of the mixture of nonionic/ionic surfactants on nanostructured lipid carriers (NLCs). Nonionic surfactant (polyethylene-poly(propylene glycol), Pluronic F68) and ionic surfactant (octenylsuccinic acid modified gum arabic, GA-OSA) were chosen as emulsifier for NLCs. The NLCs systems, which were composed of lipid matrix, modified 4-dedimethylaminosancycline (CMT-8), and various emulsifier agents, were characterized with dynamic light scattering (DLS), high performance liquid chromatography (HPLC), transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), in vitro release, and phagocytosis assay. This mixture of nonionic/ionic surfactants showed significant effects on physical properties including particle size, polydispersity index (PDI), entrapment efficiency, and particle morphology. Compared with single stabilizer, this mixed nonionic/ionic surfactant system provided NLCs with better drug carrier properties including prolonged release profile and low phagocytosis by phagocyte. We expect that these explorations can provide a new strategy for the development of lipid nanoparticles as drug delivery.