文献类型：期刊文献

英文题名：Graphene quantum dots enhance anticancer activity of cisplatin via increasing its cellular and nuclear uptake

作者：Sui, Xin[1];Luo, Chao[1];Wang, Chong[1];Zhang, Fangwei[2];Zhang, Jingyan[1];Guo, Shouwu[2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, Dept Elect Engn, Shanghai 200240, Peoples R China

年份：2016

卷号：12

期号：7

起止页码：1997

外文期刊名：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE

收录：;EI(收录号：20162602540559);WOS:【SCI-EXPANDED(收录号:WOS:000386348000025)】；

基金：This research was carried out with financial support from the national "973 Program" of China (Nos. 2015CB931801, 2014CB260411), National Science foundation of China (No. 11374205), the state key laboratory of bioreactor engineering (No. 2060204), 111 Project (No. B07023), the Shanghai Committee of Science and Technology (Nos. 11DZ2260600), and national "863" Program of China (No. 2012AA022603) for financial support of this work.

语种：英文

外文关键词：Cisplatin; Graphene quantum dots; Anticancer activity; Cell permeability; Cellular uptake

摘要：Using assistant reagents to improve the pharmaceutical performance of cisplatin ( CDDP) has been one of promising strategies. Owing to their extraordinary properties, graphene quantum dots ( GQDs) have shown great potentials in biomedical applications. Here we demonstrate that the combination of GQDs with CDDP can effectively enhance the cytotoxicity, cell cycle arrest, and DNA fragmentation that induced by CDDP. We also found that the GQDs improved the interaction of CDDP with DNA. Combing these results with our previous finding that graphene oxide could enhance the permeability of the cells, we believe GQDs improve the pharmaceutical performance of CDDP via first increasing its cellular uptake through improving the cell permeability, and then reinforcing its interaction with DNA once it is inside cells. The remarkable enhancement to CDDP cellular uptake in CDDP resistant cells further specifies that GQDs can increase chemotherapy efficacy of anticancer drugs that are suboptimal due to the drug resistance. (C) 2016 Elsevier Inc. All rights reserved.