文献类型：期刊文献

英文题名：Myricetin alleviates the formaldehyde-enhanced Warburg effect in tumor cells through inhibition of HIF-1α

作者：Li, Linyi[1,2];Ma, Huijuan[1,2];Li, Dan[1,2];Shu, Qi[1,2];Wang, Tingqian[1,2];Song, Xiaodong[3];Xu, Huan[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[3]Fudan Univ, Hua Shan Hosp North, Med Lab Dept, Shanghai 201907, Peoples R China

年份：2022

卷号：454

外文期刊名：TOXICOLOGY AND APPLIED PHARMACOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000865450100005)】；

基金：Acknowledgements This work was funded by National Natural Science Foundation of China [grant No. 21906057 and 42177417] . This work was also funded by Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission) . The manu-script is dedicated to Dr. Scott Burchiel.

语种：英文

外文关键词：Myricetin; Formaldehyde; Warburg effect; Glycolysis; HIF-1a; Tumor microenvironment

摘要：Myricetin is a flavonoid widely-distributed in foods with many beneficial health effects, which has been marketed in health products. Formaldehyde is an environmental carcinogen which can enhance the Warburg effect through the induction of human hypoxia-inducible factor 1 subunit alpha (HIF-1 alpha), the primary regulator of cellular glycolysis. HIF-1 alpha was verified as an important target in lung and ovarian tumors, which was also identified as a receptor for myricetin via molecular docking. The reinforced HIF-1 alpha signaling, the Warburg effect and T cell suppression induced by 50 mu M formaldehyde in both A549 and Caov-3 cells were dose-dependently attenuated by myricetin from 20 to 100 mu M, and the attenuative effects were diminished by the stabilization of HIF-1 alpha with deferoxamine. Exposure to 2.0 mg/m(3) formaldehyde also stimulated tumor growth and elevated HIF-1 alpha expression in tumor tissues of A549 xenograft mice, which were also alleviated by oral administration of 100 mg/kg myricetin. These results demonstrated that myricetin alleviated formaldehyde-enhanced Warburg effect in tumor cells through HIF-1 alpha inhibition, which could be further developed as a therapeutic or complementary agent for formaldehyde-induced carcinogenesis.