文献类型：期刊文献

英文题名：Overoxidized polypyrrole/multi-walled carbon nanotubes composite modified electrode for in vivo liquid chromatography-electrochemical detection of dopamine

作者：Wen, Jingxia[2]; Zhou, Li[1]; Jin, Litong[2]; Cao, Xuni[1]; Ye, Bang-Ce[1]

机构：[1] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; [2] Department of Chemistry, East China Normal University, Shanghai, 200062, China

年份：2009

卷号：877

期号：20-21

起止页码：1793

外文期刊名：Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

收录：EI(收录号：20092512141078)

语种：英文

外文关键词：Yarn - Ascorbic acid - Liquid chromatography - Chemical detection - Polypyrroles - Amines - Neurophysiology - Electrochemical electrodes

摘要：Overoxidized polypyrrole/multi-walled carbon nanotubes (OPPy/MWNTs) modified electrode has been developed for sensitively detecting dopamine (DA). OPPy films developed outside MWNTs might have a porous morphology. Thus, OPPy/MWNTs films developed by this method do not reject ascorbic acid (AA). However, OPPy/MWNTs modified electrode shows largely enhancing oxidative current responses of DA. When combined with liquid chromatography, it not only obtains a low detection limit of 7.5 × 10-10 mol L-1 for DA, but also improves the selectivity of DA detection. Mechanisms for the enhancement are also well discussed in this paper. With this approach, microdialysis has been employed for successful assessment of DA in rat striatum. ? 2009.