文献类型：期刊文献

英文题名：Near-infrared AIEgens with high singlet-oxygen yields for mitochondria-specific imaging and antitumor photodynamic therapy

作者：Zhang, Shasha[1];Yang, Wenfang[1];Lu, Xiao[2];Zhang, Xinyi[1];Pan, Zhichao[1];Qu, Da-Hui[1];Mei, Dong[2];Mei, Ju[1];Tian, He[1]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Inst Fine Chem,Sch Chem & Mol Engn,Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Clin Res Ctr, Natl Ctr Childrens Hlth, 56 South Lishi Rd, Beijing 100045, Peoples R China

年份：2023

卷号：14

期号：25

起止页码：7076

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20232714343183);WOS:【SCI-EXPANDED(收录号:WOS:001005246800001)】；

基金：We acknowledge the financial support from the National Natural Science Foundation of China (21788102, 22275055, 21875064, 81903545, and 21790361), Shanghai Science and Technology Commission Basic Project Shanghai Natural Science Foundation (21ZR1417600), Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), Programme of Introducing Talents of Discipline to Universities (B16017), Shanghai Science and Technology Committee (17520750100), Beijing New-Star Plan of Science and Technology (Z201100006820009), and the Fundamental Research Funds for the Central Universities. The authors thank the Research Center of Analysis and Test of East China University of Science and Technology for help with the characterization. All the mice used were handled strictly in accordance with governmental and international guidelines on animal experimentation. Mice were free to obtain sterile food and water. The animal experiments have been approved by the Laboratory Animal Ethics Committee of East China University of Science and Technology (No. ECUST-2021-03001).

语种：英文

外文关键词：Biocompatibility - Density functional theory - Design for testability - Infrared devices - Medical applications - Oxygen - Photodynamic therapy - Photosensitizers - Quantum yield

摘要：AIE-active photosensitizers (PSs) are promising for antitumor therapy due to their advantages of aggregation-promoted photosensitizing properties and outstanding imaging ability. High singlet-oxygen (O-1(2)) yield, near-infrared (NIR) emission, and organelle specificity are vital parameters to PSs for biomedical applications. Herein, three AIE-active PSs with D-pi-A structures are rationally designed to realize efficient O-1(2) generation, by reducing the electron-hole distribution overlap, enlarging the difference on the electron-cloud distribution at the HOMO and LUMO, and decreasing the Delta E-ST. The design principle has been expounded with the aid of time-dependent density functional theory (TD-DFT) calculations and the analysis of electron-hole distributions. The O-1(2) quantum yields of AIE-PSs developed here can be up to 6.8 times that of the commercial photosensitizer Rose Bengal under white-light irradiation, thus among the ones with the highest O-1(2) quantum yields reported so far. Moreover, the NIR AIE-PSs show mitochondria-targeting capability, low dark cytotoxicity but superb photo-cytotoxicity, and satisfactory biocompatibility. The in vivo experimental results demonstrate good antitumor efficacy for the mouse tumour model. Therefore, the present work will shed light on the development of more high-performance AIE-PSs with high PDT efficiency.