文献类型：期刊文献

中文题名：3D skin models along with skin-on-a-chip systems:A critical review

作者：Wenxuan Sun[1];Zijia Liu[1];Jian Xu[2];Ya Cheng[2];Ruixue Yin[1];Lei Ma[3];Honglin Li[3];Xuhong Qian[3,4];Hongbo Zhang[1]

机构：[1]School of Mechanical and Power Engineering,East China University of Science and Technology,Shanghai 200237,China;[2]School of Physics and Electronic Science,East China Normal University,Shanghai 200062,China;[3]School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[4]School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200062,China

年份：2023

卷号：34

期号：5

起止页码：111

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

语种：英文

中文关键词：3D skin model;Skin equivalent;Skin-on-a-chip;3D bioprinting;Skin barrier

摘要：Skin is the largest organ in human body,and it plays an important role in regulating physiological microenvironments and acts as a barrier to protect human body from harmful intrusions.The demand for fully functional skin models(also called skin equivalents,SE)in an in-vivo mimicking culturing microenvironment has been increased dramatically due to the fast development in skin disease treatments and skin care products.Owing to the emerging of the concept and technology of organ-on-chips along with the three-dimensional(3D)bioprinting technology,3D skin models and their applications have been fast evolving.In this paper,the advances in the development of 3D skin models along with skin-on-a-chip(SOC)are reviewed and commented.One of the findings with this paper is that the SOC together with the 3D bioprinting technology is promising to construct fully functional 3D skin models in the field of pharmaceutical and cosmetic industries.