文献类型：期刊文献

英文题名：Linear Alternating Supramolecular Photosensitizer for Enhanced Photodynamic Therapy

作者：Tian, Jia[1];Xia, Lei[1];Wu, Jian[1];Huang, Baoxuan[1];Cao, Hongliang[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2020

卷号：12

期号：29

起止页码：32352

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20203809186489);WOS:【SCI-EXPANDED(收录号:WOS:000555417200013)】；

基金：The authors thank the financial support by the National Natural Science Foundation of China (no. 21875063 and 51803058) and the Fundamental Research Funds for the Central Universities (no. 222201814018).

语种：英文

外文关键词：supramolecular chemistry; cyclodextrin; alternating structure; photodynamic therapy; porphyrin

摘要：Supramolecular polymers with facile and versatile architectures via noncovalent connection present great potential in biological fields. Herein, a linear alternating supramolecular polymer is constructed via host-guest inclusion interaction between cyclodextrin dimer (CD2) and bifunctional adamantane-conjugated porphyrin (TPP-Ad(2)). The supramolecular alternating structure of CD/TPP could not only suppress the aggregation of PSs to improve the photophysical properties because of the steric hindrance but also enhance the water solubility of PSs induced from cyclodextrin moieties. The nanoplatform obtained by this linear alternating supramolecular polymer (TPP-Ad(2)/CD2) presents significantly enhanced photodynamic therapy (PDT) efficacy, providing a promising path for PDT.