文献类型：期刊文献

中文题名：聚肽分子链构象转变研究

英文题名：HELIX-HELIX TRANSITIONS IN POLYPEPTIDES

作者：林嘉平[1];周达飞[1]

机构：[1]华东理工大学高分子材料系,上海200237

年份：2000

卷号：10

期号：5

起止页码：526

中文期刊名：高分子学报

外文期刊名：Acta Polymerica Sinica

收录：CSTPCD;;Scopus;北大核心:【北大核心1996】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金资助项目!(基金号59803002)

语种：中文

中文关键词：分子链构象转变;分子链构象统计理论;聚肽;NMR

外文关键词：Helix-helix translation, Statistical theory of polymer chain, Poly( β-phenethyl-L-aspartate)

摘要：聚肽分子链在一定的条件下可发生右旋分子链构象与左旋分子链构象间的构象转变 .文中提出了一个有关这一现象的统计理论解释 ,理论包含了两个重要的参数γ、ρ .γ与右旋和左旋分子链构象间能量差别有关 ;ρ与在左旋分子链段中启始一个右旋构象的结构单元所需能量有关 .进一步考虑了体系中酸分子存在对构象转变的影响 ,以解释新近发现的聚肽左、右旋多重分子链构象转变现象 .此外 ,运用核磁共振 (NMR)手段还对这一现象做了进一步的研究 .通过与实验结果和文献中报告的数据比较 ,证明这一理论可以很好地解释聚肽分子链中发生的左。
A statistical mechanical treatment concerning the helix\|helix transition of polypeptide chains was attempted based on a model which specifies the state of each peptide residue by either right\|handed screw sense or left\|handed screw sense.Two principal parameters were introduced. γ is the statistical weight of a right\|handed helical residue that follows one or more other right\|handed helical residues ρ represents the difficulty for the initiation of a right\|handed sequence after a run of left\|handed segments.To account for the newly discovered multiple helix\|helix transitions,the acid effect was further incorporated into the theory.The proposed theory was compared with experimental results and some published data,and the agreement is encouraging.