文献类型：期刊文献

英文题名：Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial

作者：Hai-Na Xie[3];Yu-Yuan Chen[1,2];Guo-Biao Zhu[1,2];Hai-Hao Han[1,2];Xi-Le Hu[1,2];Zhi-Qiang Pan[3];Zang, Yi[4];Dong-Hao Xie[5];Xiao-Peng He[1,2];Li, Jia[4];James, Tony D.[6,7]

机构：[1]East China Univ Sci & Technol, Frontiers Ctr Materiobiol & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat,Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Frontiers Ctr Materiobiol & D, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Shanghai Univ Tradit Chinese Med, Sch Basic Med Sci, 1200 Cailun Rd, Shanghai, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China;[5]Shanghai Guanghua Hosp Integrat Med, Dept Pharm, 540 Xinghua Rd, Shanghai, Peoples R China;[6]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England;[7]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

年份：2022

卷号：58

期号：32

起止页码：5029

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20221611985511);WOS:【SCI-EXPANDED(收录号:WOS:000777730700001)】；

基金：X.-P. H. thanks the National Natural Science Foundation of China (No. 21788102, 91853201), the Shanghai Science and Technology Committee (No. 19410712600), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the Fundamental Research Funds for the Central Universities (222201717003) and the Programme of Introducing Talents of Discipline to Universities (B16017) for financial support. H.-H. H. thanks the National Natural Science Foundation of China (No. 22107029) and Project funded by China Postdoctoral Science Foundation (No. 2020M681196). T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

语种：英文

外文关键词：Cancer cells - Cell culture - Diseases - Layered semiconductors - Molybdenum compounds - Supramolecular chemistry

摘要：A two-dimensional (2D) glycomaterial for targeted delivery of maytansine to liver cancer cells was developed. Host-guest interaction between a galactosyl dye and human serum albumin (HSA) produces supramolecular galactoside-HSA conjugates, which are then used to coat 2D MoS2. The 2D glycomaterial was shown to be capable of the targeted delivery of maytansine to a liver cancer cell line that highly expresses a galactose receptor, resulting in greater cytotoxicity than maytansine alone.