文献类型：期刊文献

英文题名：Highly Stereoselective C-Glycosylation by Photocatalytic Decarboxylative Alkynylation on Anomeric Position: A Facile Access to Alkynyl C-Glycosides

作者：Lu, KaiLin[1];Ma, Yingying[1];Liu, Shihui[2];Guo, Shixun[1];Zhang, Yongqiang[1]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Me, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China;[2]Jiaxing Univ, Coll Med, Jiaxing 314001, Zhejiang, Peoples R China

年份：2022

卷号：40

期号：6

起止页码：681

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000742132600001)，CCR-EXPANDED(收录号:WOS:000742132600001)】；

基金：Financial support from the program of the National Natural Science Foundation of China (No. 21871086, Y.-Q. Z.) is gratefully acknowledged.

语种：英文

外文关键词：Photocatalysis; Anomeric position; Decarboxylative alkynylation; C-C coupling; Glycosides

摘要：Comprehensive Summary The highly stereoselective synthesis of diverse medicinally valuable alkynyl C-glycosides under mild and green reaction conditions remains a great challenge. Herein, we wish to report a visible-light induced photocatalytic decarboxylative alkynylation approach. By utilizing an iridium photocatalyst in the presence of visible light, glycosyl radicals are in-situ generated via the decarboxylation of anomeric acids and efficiently coupled with a variety of ethynylbenziodoxolones (EBXs), which allows the facile synthesis of a variety of alkynyl C-glycosides in moderate to high yields and with excellent diastereoselectivity.