文献类型：期刊文献

英文题名：Synthesis of Amphiphilic Block Polyphosphoester and Exploring Its Potential in Reduction-Responsive Drug Release

作者：Li, Jinjin[1,2];Chen, Xudong[1];Jiang, Jie[1];Zhao, Ling[1,2];Xi, Zhenhao[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China

年份：2023

卷号：6

期号：1

起止页码：693

外文期刊名：ACS APPLIED POLYMER MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001143396700001)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant No. 22293064, 22378116), the Program of Shanghai Academic/Technology Researcher Leader (Grant No. 21XD1433000), the Program of Shanghai Rising-Star (Grant No. 22QA1402800), the Fundamental Research Funds for the Central Universities, the Open Project of State Key Laboratory of Chemical Engineering (SKL-ChE-21C04), and the 111 Project (Grant No. B20031).

语种：英文

外文关键词：polyphosphoester; ring-openingpolymerization; self-assembly; reduction-responsive; drug delivery

摘要：In this work, a reduction-responsive amphiphilic block polyphosphoester was synthesized via one-pot sequential organocatalytic ring-opening polymerization of 2-butoxy-1,3,2-dioxaphospholane 2-oxide (BEP) and 2-(but-3-en-1-yloxy)-1,3,2-dioxaphospholane 2-oxide (BenEP), followed by postpolymerization modification through click reaction with 2-mercaptoethanol and esterification with dithiodipropionic anhydride, respectively. The as-prepared PBEP-b-PBenEP-SS-COOH, abbreviated as PBBS, can self-assemble into well-dispersed spherical nanoparticles with an average size of about 75 nm in aqueous solution, and the nanoparticles exhibit glutathione (GSH)-triggered disassembly, which can be a promising antitumor drug carrier. Paclitaxel (PTX) encapsulation and in vitro responsive release results confirm that the PTX-loaded PBBS nanoparticles (PTX@PBBS) with drug loading content of 4.3% have an increased average size of 138 nm and exhibit a promising drug release feature with approximately 80% of PTX within 24 h incubation in the medium with 10 mM GSH. In addition, both cytotoxicity and intracellular uptake investigations demonstrate that the PBBS nanoparticles have a good biocompatibility, while PTX@PBBS can be internalized by tumor cells and efficiently release the anticancer drug PTX to inhibit the proliferation of tumor cells.