文献类型：期刊文献

英文题名：Regulation of leukemogenesis via redox metabolism

作者：Zhang, Zhuo[1,2];Chen, Chiqi[3];Li, Xie[2];Zheng, Junke[3,4];Zhao, Yuzheng[1,2]

机构：[1]East China Univ Sci & Technol, Optogenet & Synthet Biol Interdisciplinary Res Ctr, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Sch Pharm,State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Med Sci, Res Unit New Tech Live Cell Metab Imaging, Beijing 100730, Peoples R China;[3]Shanghai Jiao Tong Univ, Fac Basic Med, Sch Med, Chinese Minist Educ,Shanghai Tongren Hosp,Hongqiao, Shanghai 200025, Peoples R China;[4]Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Reprod Med, Shanghai 200025, Peoples R China

年份：2024

卷号：34

期号：11

起止页码：928

外文期刊名：TRENDS IN CELL BIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001354158500001)】；

基金：Due to space constraints, it is unavoidable that certain important works on redox metabolism are not cited and we offer our sincere apologies. We thank Y.Q. Chen for figure creation. This research is supported by the National Key Research and Development Program of China (2019YFA0904800, 2019YFA0801800) , National Natural Science Foundation of China (NSFC) (32150030, 32030065, 32121005, 92049304, 81825001, 32030030) , Shanghai Science and Technology Commission (23ZR1415800) , the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, the Research Unit of New Techniques for Live-cell Metabolic Imaging (Chinese Academy of Medical Sciences, 2019-I2M-5-013) , the innovative research team of high-level local universities in Shanghai, the State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：Redox metabolism plays a central role in the cellular metabolism network, involves catabolic and anabolic reactions of diverse biomass, and determines the redox state of cells. It can be quantitatively and conveniently measured in living cells and organisms with genetically encoded fluorescent sensors, providing novel insights that cannot be readily acquired via conventional metabolic assays. Here, we review the recent progress on the regulation of leukemogenesis via redox metabolism, especially redox biosensor-based findings. In general, low reactive oxygen species levels and high reductive capacity promote leukemogenesis and chemotherapy resistance in leukemia cells, and acute leukemia cells rewire metabolism of glucose, fatty acids, and some amino acids, together with oxidative phosphorylation, to fuel energy production, support biomass-related synthesis, and survive oxidative stress. In summary, redox metabolism is a potential target for the development of novel therapies for leukemia or beneficial dietary regimens for patients with refractory and relapsed leukemia.