文献类型：期刊文献

英文题名：Carbohydrate CuAAC click chemistry for therapy and diagnosis

作者：He, Xiao-Peng[1,2];Zeng, Ya-Li[1,2];Zang, Yi[3];Li, Jia[3];Field, Robert A.[4];Chen, Guo-Rong[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China;[4]John Innes Ctr, Dept Biol Chem, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England

年份：2016

卷号：429

起止页码：1

外文期刊名：CARBOHYDRATE RESEARCH

收录：;EI(收录号：20161702309156);WOS:【SCI-EXPANDED(收录号:WOS:000377289100001)】；

基金：This research is supported by the 973 project (2013CB733700), the National Natural Science Foundation of China (21572058 and 21576088), Key Project of the Shanghai Science and Technology Commission (13NM1400900), Fundamental Research Funds for Central Universities (222201414010), the UK BBSRC Institute Strategic Programme Grant on Understanding and Exploiting Metabolism (MET) [BB/J004561/1] and the John Innes Foundation.

语种：英文

外文关键词：Click chemistry; Carbohydrate; CuAAC; Therapy; Diagnosis

摘要：Carbohydrates are important as signaling molecules and for cellular recognition events, therefore offering scope for the development of carbohydrate-mimetic diagnostics and drug candidates. As a consequence, the construction of carbohydrate-based bioactive compounds and sensors has become an active research area. While the advent of click chemistry has greatly accelerated the progress of medicinal chemistry and chemical biology, recent literature has seen an extensive use of such approaches to construct functionally diverse carbohydrate derivatives. Here we summarize some of the progress, covering the period 2010 to mid-2015, in Cu-I-catalyzed azide-alkyne 1,3-dipolar cycloaddition CuAAC "click chemistry" of carbohydrate derivatives, in the context of potential therapeutic and diagnostic tool development. (C) 2016 The Authors. Published by Elsevier Ltd.