文献类型：期刊文献

英文题名：Porous PLGA/MBG scaffold enhanced bone regeneration through osteoimmunomodulation

作者：Liu, Yang[1,2,3];Zhang, Shuang[2,3];Zhang, Xiaohui[2,3];Ji, Luli[2,3];Yu, Hongmeng[1,4,5];Wang, Jing[2,3,6];Liu, Changsheng[2,3,6]

机构：[1]Fudan Univ, Eye & ENT Hosp, Dept Otolaryngol, Shanghai 200031, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[4]Chinese Acad Med Sci, Res Units New Technol Endoscop Surg Skull Base Tum, Beijing 100730, Peoples R China;[5]Fudan Univ, Eye & ENT Hosp, 83 Fenyang Rd, Shanghai 200031, Peoples R China;[6]East China Univ Sci & Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2024

卷号：272

外文期刊名：COMPOSITES PART B-ENGINEERING

收录：;EI(收录号：20240315398477);WOS:【SCI-EXPANDED(收录号:WOS:001156765400001)】；

基金：The authors wish to express their gratitude to the financial supports from the Key Program of the National Natural Science Foundation of China (32230059) , the Basic Science Center Program of National Natural Science Foundation of China (T2288102) , the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry (JKVD1211002) , the National Key Clinical specialty construction project (Z155080000004) , Shanghai Science and Technology Committee Foundation (21JC1401100) and the New Technologies of Endoscopic Surgery in Skull Base Tumor: CAMS Innovation Fund for Medical Sciences (CIFMS) (2019-I2M-5-003) . This study was also supported by Shanghai Xuhui District Science and Technology Committee Foundation (2021-008) and Shanghai Municipal Key Clinical Specialty (shslczdzk00801) .

语种：英文

外文关键词：Osteoimmunomodulation; Macrophage; Mesoporous bioactive glass (MBG); Bone repair and regeneration

摘要：The role of osteoimmunomodulation in orthopedic biomaterials has been demonstrated to be crucial in the regulation of bone repair and regeneration. Macrophages, the primary effector cells in the immune response to biomaterials, are highly heterogeneous and plastic, making them a prime target for immunomodulation. Mesoporous bioactive glass (MBG) is widely recognized for its biocompatibility, osteoconductivity, osteoinductivity, and immunomodulatory properties. However, the impact of MBG content on macrophage response remains unclear. To fill this knowledge gap, we designed a series of hierarchical PLGA-based composite scaffolds with varying MBG contents (0%, 10%, 20% and 40%, named as P, P10M, P20M and P40M, respectively) to investigate the osteoimmunomodulatory effects of these scaffolds. Our findings indicated that the P10M scaffolds showed a faster immune response in the early stage and exhibited superior ability to shift the pro-inflammatory immune microenvironment towards an anti-inflammatory state in the later stage, thereby enhancing the angiogenic potential of HUVECs and the osteogenic capacity of BMSCs. Furthermore, the in vivo implantation demonstrated that the immune microenvironment induced by P10M scaffolds facilitated optimal neovascularization and ectopic bone formation. These findings establish a theoretical foundation for the development of bone immunoregulatory biomaterials doped with MBG, which can effectively promote bone repair and regeneration.