文献类型：期刊文献

中文题名：微波合成羧甲基壳聚糖

英文题名：Synthesis of Carboxymethyl Chitosan by Microwave Method

作者：徐云龙[1];冯屏[2];钱秀珍[1];储文英[1];徐南苗[1]

机构：[1]华东理工大学材料学院,上海200237;[2]华东理工大学生物工程学院

年份：2003

卷号：29

期号：4

起止页码：380

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：壳聚糖;羧甲基壳聚糖;合成;微波;多次羧甲基化

外文关键词：chitosan; carboxymethyl chitosan; synthesis; microwave; multiple carboxymethylation

摘要：介绍了在微波条件下,以氯乙酸为改性剂制备羧甲基壳聚糖。探讨了反应时间、投料比和多次羧化等工艺条件对壳聚糖羧甲基化程度及产物收率的影响,并对产物进行了红外光谱分析。确定了制备羧甲基壳聚糖的最佳反应条件:氨基葡萄糖单元∶氢氧化钠∶氯乙酸=1∶20∶12(摩尔比),氨基葡萄糖单元∶异丙醇=1∶40(摩尔比),w碱=0.45,碱化温度为30°C,碱化时间为1h,羧化时间为30min,羧甲基壳聚糖取代度和收率分别达到0.95和95%。研究了多次羧甲基化反应对羧甲基壳聚糖取代度的影响,其取代度可进一步提高到1.70。
Carboxymethyl chitosan (CMC) is prepared using chloroactic acid as modifier under microwave irradiations. The effects of reaction conditions such as the reaction time and the molar ratio on the degree of carboxymethylation and the yield were discussed. The products were analyzed by infrared spectrum. The results show that the optimum reaction conditions are as follows: chitosan∶sodium hydroxide∶chloroactic acid is 1∶20∶12(molar ratio); chitosan∶isopropyl alcohol is 1∶40 (molar ratio); the mass fracton of base is 0.45; the basification temperature is 30°C; the basification time is 1 h; the carboxymethylation time is 30 min; the microwave power is 260 W. The degree and yield of CMC can reach to 0.95 and 95% respectively. The effect of multiple carboxymethylation on the degree of CMC substitution is also studied, and the degree of carboxymethylation can be improved to 1.70.