文献类型：期刊文献

英文题名：Semiclosed Cyclic Hemiaminal-Based Multistimuli- Responsive Hydrogels for Advanced Wound Dressings

作者：Yang, Yuzi[1];Pan, Fen[2,3];Jiang, Cong[4];Li, Xilong[1];Fan, Xiaoxuan[1];Sun, Zhaolong[5];Zhang, Yan[1];Wan, Shiyue[4];Chen, Pengcheng[6];Zhong, Zhengrong[6];Zhang, Peng[4];Zhang, Dapeng[1];Li, Yongsheng[1]

机构：[1]East China Univ Sci & Technol, Shanghai Engn Res Ctr Hierarch Nanomat, Key Lab Ultrafine Mat,Minist Educ,Sch Mat Sci & E, Lab Low Dimens Mat Chem, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Sch Med, Dept Clin Lab, Shanghai 200062, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Med, Inst Pediat Infect Immun & Crit Care Med, Shanghai 200062, Peoples R China;[4]Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Thorac Surg, Shanghai 200433, Peoples R China;[5]Jiangsu Univ, Res Sch Polymer Mat, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R China;[6]Shanghai Univ Tradit Chinese Med, Dept Clin Lab, Shuguang Hosp, Shanghai 201203, Peoples R China

年份：2026

卷号：27

期号：5

起止页码：3385

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20262020695737);WOS:【SCI-EXPANDED(收录号:WOS:001739367000001)】；

基金：This work was financially supported by the National Key Research and Development Program of China (Grant No. 2022YFC2403200), the National Natural Science Foundation of China (Nos. 22305081, 32571562, 52572303), Leading Talents in Shanghai in 2018, the Shanghai Sailing Program (23YF1408600), the 111 Project (B14018), and the Fundamental Research Funds for the Central Universities of China.

语种：英文

外文关键词：Bacteria - Biochemistry - Bioelectric phenomena - Ethylene

摘要：Biodegradable hydrogels represent an effective healing biomaterial for wounds. However, the fabrication of smart hydrogels containing unstable hemiaminal structures remains challenging. Here, we report a biodegradable hemiaminal-type polymeric hydrogel with formaldehyde (FA)-fixed (FP-hydrogel), synthesized via a one-pot aldimine condensation of poly(ethylene glycol) diamines (PEG-DAs) and polyformaldehyde (PFA). This design leverages the stable semiclosed eight-membered cyclic hemiaminal structures within the hydrogel network, which confer remarkable mechanical strength, self-healing capability, and plasticity. The FP-hydrogel degrades in response to diverse biological signals, including acidic pH, reactive oxygen species (ROS), and glutathione (GSH). Active FA is released from FP-hydrogel under weakly acidic conditions (pH 6.5) with a release rate of 74% and displays a significant antibacterial effect, which enables the healing of acute bacterial-infected wounds at safer FA concentrations compared to the commercial urotropine. In addition, the hydrogel effectively scavenges overexpressed ROS in chronic diabetic wounds and modulates the wound microenvironment. Consequently, it accelerates the healing processes of both acute bacteria-infected and chronic diabetic wounds in vivo due to the specific responsiveness of hemiaminal structures to multiple physiological signals in the complex wound microenvironment, demonstrating its promising use as versatile and advanced wound dressings.